2010 Fiscal Year Final Research Report
The elucidation of the intracerebral transporter control to lead the new cerebroprotection method
| Project/Area Number |
20591818
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Tokyo Medical University |
|---|
Principal Investigator |
MUROZONO Michihiro Tokyo Medical University, 医学部, 講師 (70276947)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 脳虚血 / mdr1a / 血液脳関門 |
|---|
| Research Abstract |
There is mdr1a intracranially, which blocks invasion of multi drug to brain. Mdr1 also influences displacement of endogenous substance. We made a focal cerebral ischemia model using mdr1a knockout mouse and measured blood cytokine and apoptosis-related substances such as Bcl-2 in brain. From the results, we suggest that mdr1a influences IL-6, Bcl-2 and Bax after cerebral ischemia and promotes the damage to brain.
|
Research Products
(8 results)
