2010 Fiscal Year Final Research Report
Integrated examination of the effects of general anesthetics on genomics, proteomics and metabolomics
| Project/Area Number |
20591820
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SAKAMOTO Atsuhiro Nippon Medical School, 大学院・医学研究科, 教授 (30196084)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 麻酔薬 / 遺伝子発現 / 蛋白変動 / 代謝物変動 |
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| Research Abstract |
The effects of general anesthetics on the changes of internal gene expression, protein expression and metabolites were evaluated by genomics, proteomics, and metabolomics. The main results are as follows. (1) The general anesthetics affects the clock gene expression in the brain and influences circadian rhythm. (2) The inhalational anesthetic influences the change of protein expression in the brain more than intravenous anesthetic. (3) The intravenous anesthetic influences the brain metabolism more than inhalational anesthetic. These results suggested the need of the further molecular biologic examination according to the each biological system.
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