2010 Fiscal Year Final Research Report
Molecular mechanism of responses to stress in cardiovascular system
| Project/Area Number |
20591825
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gifu University |
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Principal Investigator |
AKAMATSU Shigeru Gifu University, 医学系研究科, 非常勤講師 (20167828)
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| Co-Investigator(Kenkyū-buntansha) |
KOZAWA Osamu 岐阜大学, 医学系研究科, 教授 (90225417)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 心血管 / 血栓 / 血小板 |
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| Research Abstract |
Antithrombin III (AT-III), an anticoagulant, has recently been reported to directly affect human platelet functions. However, the exact mechanism of AT-III in platelets remains to be clarified. Our results strongly suggest that AT-III directly acts on platelets and suppresses ADP-induced platelet granule secretion such as platelet-derived growth factor-AB and serotonin due to inhibiting HSP27 phosphorylation via p44/p42 mitogen-activated protein (MAP) kinase and p38 MAP kinase.
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Research Products
(50 results)
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[Journal Article] Antithrombin III reduces collagen-stimulated granule secretion of PDGF-AB and the release of soluble CD40 ligand from human platelets.2010
Author(s)
Doi T, Adachi S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Natsume H, Kato K, Mizutani J, Otsuka T, Tokuda H, Akamatsu S, Iwama T, Kozawa O, Ogura S.
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Journal Title
Int.J.Mol.Med. 26
Pages: 387-392
Peer Reviewed
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[Journal Article] Thromboxane A_2 promotes soluble CD40 ligand release from human platelets.2010
Author(s)
Enomoto Y, Adachi S, Matsushima-Nishiwaki R, Doi T, Niwa M, Akamatsu S, Tokuda H, Ogura S, Yoshimura S, Iwama T, Kozawa O.
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Journal Title
Atherosclerosis 209
Pages: 415-421
Peer Reviewed
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[Journal Article] Mechanism of collagen-induced release of 5-HT, PDGF-AB and sCD40L from human platelets : role of HSP27 phosphorylation via p44/p42 MAPK.2010
Author(s)
Kato H, Adachi S, Doi T, Matsushima-Nishiwaki R, Minamitani C, Akamatsu S, Enomoto Y, Tokuda H, Otsuka T, Iwama T, Kozawa O, Ogura S.
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Journal Title
Thromb.Res. 126
Pages: 39-43
Peer Reviewed
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[Journal Article] Antithrombin III suppresses ADP-induced platelet granule secretion : inhibition of HSP27 phosphorylation.2009
Author(s)
Doi T, Adachi S, Takai S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Minamitani C, Otsuka T, Tokuda H, Akamatsu S, Iwama T, Kozawa O, Ogura S.
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Journal Title
Arch.Biochem.Biophys. 489
Pages: 62-67
Peer Reviewed
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[Journal Article] αB-crystallin extracellularly suppresses ADP-induced granule secretion from human platelets.2009
Author(s)
Enomoto Y, Adachi S, Matsushima-Nishiwaki R, Niwa M, Tokuda H, Akamatsu S, Doi T, Kato H, Yoshimura S, Ogura S, Iwama T, Kozawa O.
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Journal Title
FEBS Lett. 583
Pages: 2464-2468
Peer Reviewed
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[Journal Article] Level of collagen-induced p38 MAP kinase activation is a biomarker of platelet hyper-aggregation in patients with diabetes mellitus.2009
Author(s)
Hanai Y, Adachi S, Yasuda I, Takai S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Akamatsu S, Sakakibara S, Ogura S, Iwama T, Kozawa O, Tokuda H.
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Journal Title
Life Sci. 85
Pages: 386-394
Peer Reviewed
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[Journal Article] HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion.2008
Author(s)
Kato H, Takai S, Matsushima-Nishiwaki R, Adachi S, Minamitani C, Otsuka T, Tokuda H, Akamatsu S, Doi T, Ogura S, Kozawa O.
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Journal Title
Arch.Biochem.Biophys. 475
Pages: 80-86
Peer Reviewed
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[Journal Article] cAMP regulates ADP-induced HSP27 phosphorylation in human platelets.
Author(s)
Enomoto Y, Adachi S, Doi T, Natsume H, Kato K, Matsushima-Nishiwaki R, Akamatsu S, Tokuda H, Yoshimura S, Otsuka T, Ogura S, Kozawa O, Iwama T.
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Journal Title
Peer Reviewed
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[Presentation] 胃癌術後に褥瘡感染から壊死性筋膜炎,敗血症性ARDSを発症,PMX-DHPを施行し救命できた1例2008
Author(s)
河田陵, 小林建司, 赤松繁, 佐藤知洋, 東雅朗, 湯澤浩之, 上田修久, 花立史香, 清水幸雄, 松波英寿
Organizer
第70回日本臨床外科学会
Place of Presentation
東京
Year and Date
2008-11-29
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[Presentation] 産褥性心筋症の一例2008
Author(s)
森下健太郎, 小島好修, 森田則彦, 丹羽崇, 赤松繁
Organizer
第16回日本集中治療医学会東海北陸地方会
Place of Presentation
岐阜
Year and Date
2008-07-05
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[Remarks] ホームページ等
