2010 Fiscal Year Final Research Report
Analysis of cardiac viability after myocardial ischemia and infarction.
| Project/Area Number |
20591827
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
YAMAZAKI Toji 滋賀医科大学, 医学部, 非常勤講師 (20116122)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Hirotoshi 滋賀医科大学, 医学部, 講師 (50252391)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 周術期管理学 |
|---|
| Research Abstract |
The present study describes a measurement of the dialysate cardiac marker and neurotranmitter levels found in the myocardial interstitial space. Using this cardiac microdialysis technique, myoglobin, as one of the cardiac muscle proteins, release evoked by the desipramine(cell injury-induced drug) was detected as an index of cardiac viability. This index decreased in proportion to the ischemia time. Ischemic preconditioning enhances preservation in cardiac viability. This system offers a new possibility for monitoring cardiac viability after cardiac ischemia/infarction.
|
