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2010 Fiscal Year Final Research Report

Development of a new therapy using i-RNA method in a newly created pulmonary hypertension model in mice

Research Project

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Project/Area Number 20591844
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionJikei University School of Medicine

Principal Investigator

UEZONO Shoichi  Jikei University School of Medicine, 医学部, 教授 (10291676)

Project Period (FY) 2008 – 2010
Keywords肺高血圧 / マウス / 血管リモデリング / 核内転写因子 / 核酸医薬
Research Abstract

Remodeling of pulmonary vasculature (neointimal formation) is a key pathophysiology of development of pulmonary hypertension. The primary purpose of this research is to establish severe form of pulmonary hypertension model in mice. We observed that three-week-long exposure to hypoxic (FiO2=17%) environment with monocrotaline injection caused severe pulmonary hypertension. Unfortunately, more than 50% of these pulmonary hypertensive mice were too sick to tolerate an experiment of measurement of pulmonary artery pressure, necessitating abandon of this experimental model. Using a large cohort of pregnant women with congenital heart disease, we revealed the presence of pulmonary hypertension is a risk factor for maternal and neonatal poor outcome of pregnancy.

  • Research Products

    (2 results)

All 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] A Retrospective 7-Year Single-Center Survey of Adverse Maternal and Neonatal Outcomes for Parturients with Congenital Heart Disease : Mode of Delivery and Anesthetic Management2011

    • Author(s)
      Hidano G, Uezono S, Terui K
    • Journal Title

      International journal of bstetric anesthesia

    • Peer Reviewed
  • [Journal Article] Anesthetic management of noncardiac surgery for patients with single ventricle physiology2011

    • Author(s)
      Yuki K, A. Casta A, Uezono S
    • Journal Title

      巻25

      Pages: 247-256

    • Peer Reviewed

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

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