2010 Fiscal Year Final Research Report
Reduction of intraoperative third space by low-molecular weight plasma substitute
| Project/Area Number |
20591846
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
TATARA Tsuneo Hyogo College of Medicine, 医学部, 教授 (30207039)
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| Co-Investigator(Kenkyū-buntansha) |
KARIYA Nobutaka 兵庫医科大学, 医学部, 准教授 (20305642)
UEKI Ryusuke 兵庫医科大学, 医学部, 講師 (10340986)
TASHIRO Chikara 兵庫医科大学, 医学部, 病院長 (20107048)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 周術期管理学 |
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| Research Abstract |
Tissue edema during surgery delays recovery after surgery. This study investigated whether low-molecular weight (MW) hydroxyethyl starch (HES) solution reduces tissue edema during surgery. Low-MW HES significantly inhibited solute diffusion from polyacrylamide gel compared to high-MW HES. However, degree of tissue edema in patients undergoing open abdominal surgery was comparable for low-MW and high-MW HES, suggesting no apparent effect of reduction of tissue edema for low-MW HES.
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Research Products
(19 results)
