2010 Fiscal Year Final Research Report
Impact of endocrine environment on the development, biological features and progression of prostate cancer.
| Project/Area Number |
20591851
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Gunma University |
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Principal Investigator |
ITO Kazuto Gunma University, 大学院・医学系研究科, 准教授 (00302472)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 前立腺癌 / 性ホルモン / テストステロン / コルチゾール / コルチゾン / 前立腺特異抗原 |
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| Research Abstract |
Increased serum cholesterol concentration due to westernized diet may affect mineral corticoids concentration and following changes in sex hormone environment in human. In the present study, we investigated correlation between serum sex hormones and promotion of prostate cancer. A case control study demonstrated that patients diagnosed with prostate cancer had significantly higher serum pregnenolone (P5) level and lower both estradiol and 11-deoxycorticosterone levels in the serum taken several years ago compared with men without clinically manifested prostate cancer. An acceleration of converting enzyme, CYP11A1, may play some role to lead such a specific endocrine feature and following cancer development.
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