Research for a mechanism of prostate cancer metastasis through a SPA-1(Rap1GAP) signaling pathway.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591855
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Kyoto University
• Principal Investigator: YOSHIMURA Kouji Kyoto University, 医学研究科, 講師 (40397542)
• Co-Investigator(Kenkyū-buntansha): OGAWA Osamu 京都大学, 医学研究科, 教授 (90260611) ; NAKAMURA Eijirou 京都大学, 医学研究科, 講師 (90293878) ; KANEMATSU Akihiro 京都大学, 医学研究科, 助教 (90437202)
• Co-Investigator(Renkei-kenkyūsha): MINATO Nagahiro 京都大学, 生命科学研究科, 教授 (40137716) ; HATTORI Masakazu 京都大学, 生命科学研究科, 准教授 (40211479)
• Project Period (FY): 2008 – 2010
• Keywords: 前立腺癌 / Rap1 / Spa-1 / 転移

Research Abstract

The expression of SPA-1, one of the Rap1GAPs, was increased in metastatic tissues of human prostate cancer, compared with the primary sites. Based on the results, we found that SPA-1 protein promotes the invasion and metastasis of prostate cancer, by down-regulation of attachment to ECM through Rap1's inactivation and by suppressing transcription of ECM-asscociated genes through translocation of Brd4.

Research Products

• [Journal Article] SPA-1 controls the invasion and metastasis of human prostate cancer. (2011)
  • Author(s): Yosuke Shimizu, Yoko Hamazaki, Masakazu Hattori, Keiko Doi, Naoki Terada, Takashi Kobayashi, Yoshinobu Toda, Toshinari Yamasaki, Takahiro Inoue, Yoichiro Kajita, Atsushi Maeno, Tomomi Kamba, Yoshiki Mikami, Toshiyuki Kamoto, Tomomi Yamada, Toru Kanno, Kiyotsugu Yoshikawa, Osamu Ogawa, Nagahiro Minato, Eijiro Nakamura.
  • Journal Title: Cancer Sci 102 Pages: 828-836
  • Peer Reviewed
• [Journal Article] Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population. (2008)
  • Author(s): Terada N, Nakamura E, Ogawa O, et al.
  • Journal Title: Prostate 68 Pages: 1689-1695
  • Peer Reviewed
• [Presentation] ヒト前立腺癌におけるRap1 Gap SPA-1 を介した転移機序の解明 (2010)
  • Author(s): 清水洋祐、中村英二郎、小川修、ほか
  • Organizer: 第48回日本癌治療学会
  • Place of Presentation: 京都府京都市
  • Year and Date: 2010-10-28
• [Presentation] Spa-1 (SIPA1) CONTROLS THE INVASION AND METASTASIS OF HUMAN PROSTATE CANCERS VIA RAP SIGNAL. (2009)
  • Author(s): 清水洋祐、中村英二郎、小川修、ほか
  • Organizer: 第26回日韓泌尿器科会議
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2009-09-19
• [Presentation] ヒト前立腺癌におけるRapl GAP SPA-1 を介した転移機序の解明 (2008)
  • Author(s): 清水洋祐, 中村英二郎, 小川修, ほか
  • Organizer: 第67回癌学会学術総会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2008-10-28
• [Presentation] ヒト前立腺癌におけるSPA-1 を介した転移機序の解明 (2008)
  • Author(s): 清水洋祐, 中村英二郎, 小川修, ほか
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2008-04-25
• [Remarks] ホームページ等
  • URL: http://www.urology.kuhp.kyoto-u.ac.jp