2010 Fiscal Year Final Research Report
Developing new diagnostic kit for prostate cancer through detecting methylated DNA in urine sample
| Project/Area Number |
20591860
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kagoshima University |
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Principal Investigator |
ENOKIDA Hideki Kagoshima University, 医歯学総合研究科, 講師 (80347103)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Masayuki 鹿児島大学, 医歯学総合研究科, 教授 (90164144)
KAWAMOTO Ken 鹿児島大学, 医歯学総合研究科, 研究員 (80363620)
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| Research Collaborator |
千代丸 剛 鹿児島大学, 医歯学総合研究科, 大学院生
鑪野 秀一 鹿児島大学, 医歯学総合研究科, 大学院生
吉野 裕史 鹿児島大学, 医歯学総合研究科, 大学院生
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| Project Period (FY) |
2008 – 2010
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| Keywords | 前立腺癌 / 尿 / メチル化 / 診断 |
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| Research Abstract |
We screened methylated DNA by using oligomicroarray analyses of prostate cancer cell lines treated by a demethylating agent and focused on APC, GSTP1, and MT1G. Prostate tissues and urine samples were used for extracting their DNA, which were subjected to methylation specific PCR. The methylation status of MT1G was significantly associated with tumor stage. These markers may have potential abilities to distinguish prostate cancer from benign prostate hypertrophy.
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[Journal Article] Secreted frizzled-related protein-5 is epigenetically downregulated and functions as a tumor suppressor in kidney cancer.2011
Author(s)
Kawakami K, Yamamura S, Hirata H, Ueno K, Saini S, Majid S, Tanaka Y, Kawamoto K, Enokida H, Nakagawa M, Dahiya R.
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Journal Title
Int J Cancer. 128
Pages: 541-550
Peer Reviewed
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[Journal Article] CpG hypermethylation of cellular retinol-binding protein 1 contributes to cell proliferation and migration in bladder cancer.2010
Author(s)
Toki K, Enokida H, Kawakami K, Chiyomaru T, Tatarano S, Yoshino H, Uchida Y, Kawahara K, Nishiyama K, Seki N, Nakagawa M.
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Journal Title
Int J Oncol. 37
Pages: 1379-1388
Peer Reviewed
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[Journal Article] Functional significance of Wnt inhibitory factor-1 gene in kidney cancer.2009
Author(s)
Kawakami K, Hirata H, Yamamura S, Kikuno N, Saini S, Majid S, Tanaka Y, Kawamoto K, Enokida H, Nakagawa M, Dahiya R.
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Journal Title
Cancer Res. 69
Pages: 8603-8610
Peer Reviewed
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[Journal Article] CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma.2008
Author(s)
Kagara I, Enokida H, Kawakami K, Matsuda R, Toki K, Nishimura H, Chiyomaru T, Tatarano S, Itesako T, Kawamoto K, Nishiyama K, Seki N, Nakagawa M
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Journal Title
J Urol. 180
Pages: 343-351
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