2010 Fiscal Year Final Research Report
The search of the prostate cancer marker based on blood carbohydrate chain structure and the establishment of the diagnostic method
| Project/Area Number |
20591867
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Juntendo University |
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Principal Investigator |
FUJIMURA Tsutomu Juntendo University, 医学(系)研究科, 准教授 (70245778)
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| Co-Investigator(Kenkyū-buntansha) |
KAZUNO SAIKO 順天堂大学, 医学(系)研究科(研究院), 助教 (00338344)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 腫瘍学 |
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| Research Abstract |
Postate-specific antigen (PSA) has been widely used for detection and diagnosis of prostate cancer. But a false-positive is high in the diagnosis of the prostate cancer when I use PSA. I compared glycosylation haptoglobin as a prostate cancer marker as alternated PSA. The sialylation and fucosylation of the haptoglobin significantly rose with prostate cancer serum .I showed the possibility of a diagnostic method used as tumor marker of the novel prostate cancer that haptoglobin was based on blood carbohydrate structure.
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