Conditionally Replicative Adenovirus for Targeting Bladder Cancer.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591871
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Hyogo College of Medicine
• Principal Investigator: TERAO Shuji Hyogo College of Medicine, 医学部, 助教 (10457103)
• Co-Investigator(Kenkyū-buntansha): GOTOH Akinobu 兵庫医科大学, 医学部, 教授 (70283885)
• Co-Investigator(Renkei-kenkyūsha): FUJISAWA Masato 神戸大学, 医学部, 教授 (30243314) ; TAGAWA Masatoshi 千葉県がんセンター, 病理研究部, 部長 (20171572)
• Project Period (FY): 2008 – 2010
• Keywords: 膀胱癌 / 遺伝子治療 / AdMKE1a / 導入効率 / バルプロ酸Na

Research Abstract

In this study, we examined whether the pre-treatment of valproic acid enhance the therapeutic effect of gene therapy using adenovirus vector for bladder cancer which do not have a significant effect on therapeutic outcome of adenovirus gene therapy. Our data showed the feasibility of the enhancement of adenovirus gene therapy using the pre-treatment of valproic acid in in vitro and in vivo.

Research Products

• [Journal Article] 膀胱癌の遺伝子治療 (2010)
  • Author(s): 後藤章暢,寺尾秀治
  • Journal Title: 日本臨牀腎・泌尿器科癌 68増刊号4 Pages: 230-4
• [Journal Article] A pilot study of quality of life of patients with hormone-refractory prostate cancer after gene therapy. (2009)
  • Author(s): Terao S, Shirakawa T, Acharya B, Miyata M, Hinata N, Tanaka K, Takenaka A, Hara I, Naoe M, Fuji K, Okegawa T, Higashihara E, Kamidono S, Fujisawa M, Gotoh A
  • Journal Title: Anticancer Res 29 Pages: 1533-7
  • Peer Reviewed
• [Journal Article] Improved gene transfer into renal carcinoma cells using adenovirus vector containing RGD motif. (2009)
  • Author(s): Terao S, Acharya B, Suzuki T, Aoi T, Naoe M, Hamada K, Mizuguchi H, Gotoh A
  • Journal Title: Anticancer Res 29 Pages: 2997-3001
  • Peer Reviewed
• [Journal Article] 遺伝子治療の展望 (2009)
  • Author(s): 後藤章暢,寺尾秀治
  • Journal Title: Urology View 7 Pages: 102-8
  • Peer Reviewed
• [Presentation] ヒト膀胱癌細胞株に対するIAI.3Bプロモーターを組み込んだ制限増殖型アデノウイルスベクターの有用性の検討 (2010)
  • Author(s): 寺尾秀治,Acharya B,鈴木透,後藤章暢
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-04-28
• [Presentation] ヒト膀胱癌細胞株に対するIAI.3Bプロモーターを組み込んだ制限増殖型アデノウイルスベクターの有用性の検討 (2009)
  • Author(s): 寺尾秀治,Acharya B,鈴木透,濱田雄行,後藤章暢
  • Organizer: 第59回日本泌尿器科学会中部総会
  • Place of Presentation: 金沢
  • Year and Date: 2009-10-29
• [Presentation] Improved gene transfer into renal carcinoma cells using an adenovirus vector. (2009)
  • Author(s): Terao S, Acharya B, Suzuki T, Gotoh A
  • Organizer: The 19th Annual Meeting of the International Urological Conference of Taiwan
  • Place of Presentation: Kaohsiung, Taiwan
  • Year and Date: 2009-08-28
• [Presentation] 膀胱癌細胞株に対するアデノウイルスベクターの導入効率向上の試み (2009)
  • Author(s): 寺尾秀治,Acharya B,鈴木透,濱田雄行,水口裕之,後藤章暢
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2009-04-17
• [Presentation] ヒト膀胱癌細胞に対するミドカインプロモーターを組み込んだ増殖制限型アデノウイルスベクター(ADMKE1a)の有用性の検討 (2008)
  • Author(s): 寺尾秀治,白川利朗,Acharya, B.,鈴木透,乃美昌司,濱田雄行,田川雅敏,田中一志,武中篤,藤澤正人,後藤章暢
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Therapeutic efficacy of midkine promoter-based conditionally replicative adenovirus vector for targeting the midkine-expressing human bladder cancer cells. (2008)
  • Author(s): Terao S, Shirakawa, T., Acharya, B., Suzuki, T., Hamada, K., Tagawa, M., Tanaka, K., Takenaka, A., Fujisawa, M., Gotoh A
  • Organizer: 2008 International Society for Cell and Gene Therapy of Cancer China Conference
  • Place of Presentation: Shijiazhuang, China
  • Year and Date: 2008-09-20
• [Presentation] Therapeutic efficacy of midkine promoter-based conditionally replicative adenovirus vector for targeting the midkine-expressing human bladder cancer cells. (2008)
  • Author(s): Terao S, Shirakawa T., Tanaka K., Takenaka A., Kamidono S., Fujisawa M. Gotoh A
  • Organizer: American Urological Association 2008 Annual Meeting(AUA2008)
  • Place of Presentation: Orlando. U.S.A.
  • Year and Date: 2008-05-18