2010 Fiscal Year Final Research Report
Role of bone marrow stromal cells in the bladder with partial outlet obstruction
| Project/Area Number |
20591873
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Hokkaido University |
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Principal Investigator |
MITSUI Takahiko Hokkaido University, 病院, 助教 (90421966)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Hiroshi 北海道大学, 病院, 講師 (60344470)
NONOMURA Katsuya 北海道大学, 大学院・医学研究科, 教授 (60113750)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 骨髄由来細胞 / 下部尿路閉塞 / 下部尿路機能障害 / 膀胱上皮 / GFP |
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| Research Abstract |
Using rats with allogenic bone marrow transplants from transgenic rats expressing green fluorescent protein, we investigated the contributions of bone marrow derived stem cells (BMCs) to the regeneration of the bladder with partial bladder outlet obstruction (PBOO). BMCs were homed into the PBOO bladder, and those cells have potential to differentiate into the bladder tissue components such as the uroepithelium cells, the myofibroblast cells, and smooth muscle cells in the bladder with PBOO.
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