2010 Fiscal Year Final Research Report
Study on new treatment strategy for bladder storage dysfunction
| Project/Area Number |
20591875
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Shinshu University |
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Principal Investigator |
IGAWA Yasuhiko Shinshu University, 医学部附属病院, 特任教授 (40159588)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Teruyuki 信州大学, 医学部, 特任助教 (90467142)
AIZAWA Naoki 東京大学, 医学部附属病院, 特任助教 (80595257)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 排尿学 |
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| Research Abstract |
Electrophysiological investigation in the rat revealed that beta3-AR agonists and activation of L-arginine/NO inhibit mechanosensitive afferent nerve activities primarily originating from the bladder in response to bladder distension as well as increased afferent nerve activities induced by intravesical instillation of PGE_2 and acrolein, respectively. Freeze-injured mouse bladders implanted with human amniotic mesenchymal cells recovered morphology and function faster than control-injected bladders. CXCL10 in the bladder urothelium and urine increased in ulcer type interstitial cystitis, suggesting its possible use as a biomarker.
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Research Products
(34 results)
