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2010 Fiscal Year Final Research Report

Research for establishment of prevention for urolithiasis by considering metabolic syndrome

Research Project

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Project/Area Number 20591885
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionNagoya City University

Principal Investigator

ITOH Yasunori  Nagoya City University, 大学院・医学研究科, 研究員 (70295608)

Co-Investigator(Kenkyū-buntansha) OKADA Atsushi  名古屋市立大学, 大学院・医学研究科, 助教 (70444966)
YASUI Takahiro  名古屋市立大学, 大学院・医学研究科, 講師 (40326153)
TOZAWA Keiichi  名古屋市立大学, 大学院・医学研究科, 准教授 (40264733)
KOHRI Kenjiro  名古屋市立大学, 大学院・医学研究科, 教授 (30122047)
Project Period (FY) 2008 – 2010
Keywords尿路結石症 / メタボリックシンドローム / アディポサイトカイン / ストレス感受性シグナル / オステオポンチン / 結石モデルマウス / OPNノックアウトマウス / OPNトランスジェニックマウス
Research Abstract

Urolithiasis looks like metabolic syndrome about mechanism of generation. Then, we performed research for establishment of prevention for urolithiasis by considering metabolic syndrome from genetic and environmental factors. In genetic research, we analyzed SNPs of the OPN gene and compared their results to patients' background and stone composition. We found the specific SNPs as a risk marker for stone recurrence. In environmental research, we found that NFκB as a stress receptivity signal was increased and mitochondria was received injury by oxidative stress.

  • Research Products

    (35 results)

All 2010 2009 2008

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (16 results) Book (5 results)

  • [Journal Article] The Mechanism of renal stone formation and renal failure induced by administration of melamine and cyanuric acid.2010

    • Author(s)
      Kobayashi Takahiro, Okada Atsushi, Fujii Yasuhiro, Niimi Kazuhiro, Hamamoto Shuzo, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
    • Journal Title

      Urological Research 38

      Pages: 117-125

    • Peer Reviewed
  • [Journal Article] Renal tubular epithelial cell injury and oxidative stress induce calcium oxalate crystal formation in mouse kidney.2010

    • Author(s)
      Hirose Masahito, Yasui Takahiro, Okada Atsushi, Hamamoto Shuzo, Shimizu Hideo, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
    • Journal Title

      International Journal of Urology 17

      Pages: 83-93

    • Peer Reviewed
  • [Journal Article] The single-knot method with Lapra-Ty clips is useful for training surgeons in vesicourethral anastomosis during laparoscopic radical prostatectomy.2009

    • Author(s)
      Yasui Takahiro, Itoh Yasunori, Maruyama Tetsuji, Akita Hidetoshi, Hashimoto Yoshihiro, Tozawa Keiichi, Kohri Kenjiro
    • Journal Title

      International Urology and Nephrology 41

      Pages: 281-285

    • Peer Reviewed
  • [Journal Article] Genome-wide analysis of genes related to kidney stone formation and elimination in the calcium oxalate nephrolithiasis model mouse : detection of stone-preventive factors and involvement of macrophage activity.2009

    • Author(s)
      Okada Atsushi, Yasui Takahiro, Hamamoto Shuzo, Hirose Masahito, Kubota Yasue, Itoh Yasunori, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro
    • Journal Title

      Journal of Bone and Mineral Research 24

      Pages: 908-924

    • Peer Reviewed
  • [Journal Article] Alendronate reduces the excretion of risk factors for calcium phosphate stone formation in postmenopausal women with osteoporosis.2009

    • Author(s)
      Yasui Takahiro, Itoh Yasunori, Okada Atsushi, Hamamoto Shuzo, Hirose Masahito, Kobayashi Takahiro, Tozawa Keiichi, Kohri Kenjiro
    • Journal Title

      Urologia Internationalis 83

      Pages: 226-229

    • Peer Reviewed
  • [Journal Article] Effects of silodosin and naftopidil on distal ureter and cardiovascular system in anesthetized dogs : Comparison of potential medications for distal ureteral stone passage.2009

    • Author(s)
      Kobayashi Shinya, Tomiyama Yoshitaka, Hoyano Yuji, Yamazaki Yoshinobu, Sasaki Shoichi, Kohri Kenjiro
    • Journal Title

      Journal of Urology 183

      Pages: 357-361

    • Peer Reviewed
  • [Journal Article] Gene expressions and mechanical functions of α_1-adrenoceptro subtypes in mouse ureter.2009

    • Author(s)
      Kobayashi Shinya, Tomiyama Yoshitaka, Hoyano Yuji, Yamazaki Yoshinobu, Kusama Hiroshi, Itoh Yasunori, Kubota Yasue, Kohri Kenjiro
    • Journal Title

      World Journal of Urology 27

      Pages: 775-780

    • Peer Reviewed
  • [Journal Article] Evaluation of operative complications related to laparoscopic radical prostatectomy.2008

    • Author(s)
      Tozawa Keiichi, Hashimoto Yoshihiro, Yasui Takahiro, Itoh Yasunori, Nagata Daisuke, Akita Hidetoshi, Kawai Noriyasu, Hayashi Yutaro, Kohri Kenjiro
    • Journal Title

      International Journal of Urology 15

      Pages: 222-225

    • Peer Reviewed
  • [Journal Article] Prevalence and epidemiological characteristics of urolithiasis in Japan : National trends between 1965 and 2005.2008

    • Author(s)
      Yasui Takahiro, Iguchi Masanori, Suzuki Sadao, Kohri Kenjiro
    • Journal Title

      Urology 71

      Pages: 209-213

    • Peer Reviewed
  • [Journal Article] Impact of microwave tissue coagulation during laparoscopic partial nephrectomy on postoperative renal function.2008

    • Author(s)
      Yasui Takahiro, Itoh Yasunori, Kojima Yoshiyuki, Umemoto Yukihiro, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
    • Journal Title

      International Urology and Nephrology 40

      Pages: 277-282

    • Peer Reviewed
  • [Journal Article] Eicosapentaenoic acid has a preventive effect on the recurrence of nephrolithiasis.2008

    • Author(s)
      Yasui Takahiro, Suzuki Sadao, Itoh Yasunori, Tozawa Keiichi, Tokudome Shinkan, Kohri Kenjiro
    • Journal Title

      Urologia Internationalis 81

      Pages: 135-138

    • Peer Reviewed
  • [Journal Article] NF-_κB activation in renal tubular epithelial cells by oxalate stimulation.2008

    • Author(s)
      Tozawa Keiichi, Yasui Takahiro, Okada Atsushi, Hirose Masahito, Hamamoto Shuzo, Itoh Yasunori, Kohri Kenjiro
    • Journal Title

      International Journal of Urology 15

      Pages: 924-928

    • Peer Reviewed
  • [Journal Article] Risk of renal stone formation induced by long-term bed rest could be decreased by premedication with bisphosphonate and increased by resistive exercise.2008

    • Author(s)
      Okada Atsushi, Ohshima Hiroshi, Itoh Yasunori, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
    • Journal Title

      International Journal of Urology 15

      Pages: 630-635

    • Peer Reviewed
  • [Journal Article] Prevalence and epidemiologic characteristics of lower urinary tract stones in Japan.2008

    • Author(s)
      Yasui Takahiro, Iguchi Masanori, Suzuki Sadao, Okada Atsushi, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
    • Journal Title

      Urology 72

      Pages: 1001-1005

    • Peer Reviewed
  • [Presentation] Overexpression of Cdc25A, an androgen receptor coactivator, in human prostage cancer.2009

    • Author(s)
      Hashimoto Yoshihiro, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] Satisfaction with voiding, appearance, and sexual function in adolescents after hypospadias repair during childhood.2009

    • Author(s)
      Nakane Akihiro, Hayashi Yutaro, Kurokawa Satoshi, Kamisawa Hideyuki, Imura Makoto, Mizuno Kentaro, Kato Toshiki, Kojima Yoshiyuki, Maruyama Tetsuji, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] Disturbance of testicular development during testicular tubule formation causes vanishing testis.2009

    • Author(s)
      Hayashi Yutaro, Kojima Yoshiyuki, Mizuno Kentaro, Kurokawa Satoshi, Nakane Akihiro, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] Relationship between testicular location and the genetic characteristics of germ cells in cryptorchidism.2009

    • Author(s)
      Mizuno Kentaro, Kojima Yoshiyuki, Kurokawa Satoshi, Iwatsuki Shoichiro, Kamisawa Hideyuki, Shibata Yasuhiro, Maruyama Tetsuji, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] Expression of the estrogen receptor alpha is decreased in the cryptorchid rat testes.2009

    • Author(s)
      Mizuno Kentaro, Kojima Yoshiyuki, Kurokawa Satoshi, Iwatsuki Shoichiro, Kamisawa Hideyuki, Shibata Yasuhiro, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] The new findings of signal intensity on T2-weighted-MR imaging may enable preoperative diagnosis of vanishing testes.2009

    • Author(s)
      Kato Toshiki, Kojima Yoshiyuki, Mizuno Kentaro, Kamisawa Hideyuki, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] Prostate growth inhibition by subtype-selective alpha1-adrenoceptor antagonist naftopidil in benign prostatic hyperplasia.2009

    • Author(s)
      Kojima Yoshiyuki, Sasaki Shoichi, Oda Nobuyuki, Hayase Masa, Kubota Yasue, Hayashi Yutaro, Kiniwa Mamoru, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] Alendronate has a preventive effect on the recurrence of nephrolithiasis by reducing the risk factors of calcium stone.2009

    • Author(s)
      Yasui Takahiro, Okada Atsushi, Usami Masayuki, Hamamoto Shuzo, Kobayashi Takahiro, Hirose Masahito, Itoh Yasunori, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] Dietary soy isoflavone replacement improves detrusor overactivity of ovariectomized rats with alteration of connexin-43 expression in the urinary bladder.2009

    • Author(s)
      Okada Shinsuke, Kojima Yoshiyuki, Hamamoto Shuzo, Mizuno Kentaro, Kubota Yasue, Sasaki Shoichi, Tsugaya Masayuki, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] Genome-wide association study identifies new susceptibility loci for urolithiasis.2009

    • Author(s)
      Usami Masayuki, Itoh Yasunori, Tozawa Keiichi, Matsuda Koichi, Nakamura Yusuke, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] Osteopontin has an important role in kidney stone formation and elimination via renal macrophage recruitment and activation.2009

    • Author(s)
      Okada Atsushi, Tozawa Keiichi, Niimi Kazuhiro, Hirose Yasuhiko, Kobayashi Takahiro, Usami Masayuki, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Hayashi Yutaro, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] Cyclooxygenase-2 appears to be induced in the testes of experimental cryptorchidism in order to reduce the apoptosis of germ cells and may have a key role on protection of germ cells from heat-stress.2009

    • Author(s)
      Kubota Hiroki, Kubota Yasue, Umemoto Yukihiro, Kaneko Tomoyoshi, Yanai Yoshimasa, Sasaki Shoichi, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] Essential role of Chk1 in S phase progression through regulation of RNR2 expression.2009

    • Author(s)
      Naruyama Hiromichi, Hashimoto Yoshiyuki, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] Effects of microgravity enhancement of oxidative stress in human renal tubular cells.2009

    • Author(s)
      Itoh Yasunori, Yasui Takahiro, Okada Atsushi, Hirose Masahito, Hamamoto Shuzo, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] The melamine stone : The mechanism of renal calculus formation from melamine exposure.2009

    • Author(s)
      Kobayashi Takahiro, Okada Atsushi, Usami Masayuki, Hamamoto Shuzo, Hirose Masahito, Yasui Takahiro, Itoh Yasunori, Tozawa Keiichi, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Presentation] The role of NF-KB on renal stone formation.2009

    • Author(s)
      Tozawa Keiichi, Yasui Takahiro, Hirose Masahito, Usami Masayuki, Hamamoto Shuzo, Hirose Yasuhiko, Okada Atsushi, Itoh Yasunori, Hayashi Yutaro, Kohri Kenjiro
    • Organizer
      AUA 2009 Annual Meeting
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      20090425-20090430
  • [Book] 腎と透析、69(宇宙飛行士の水・電解質管理)2010

    • Author(s)
      伊藤恭典、郡健二郎
    • Total Pages
      694
  • [Book] 外科治療、101(導尿と膀胱穿刺)2009

    • Author(s)
      伊藤恭典、郡健二郎
    • Total Pages
      328-332
  • [Book] 腎と透析、67(アンモニア代謝異常と尿路結石症)2009

    • Author(s)
      伊藤恭典、郡健二郎
    • Total Pages
      69-72
  • [Book] 泌尿器科外科、29(尿路結石症診療ガイドライン)2009

    • Author(s)
      伊藤恭典、郡健二郎
    • Total Pages
      1193-1196
  • [Book] 初学者から専門医までの腎臓学入門 改訂第二版(泌尿器科疾患と腎-尿路感染症・尿路結石症・嚢胞性疾患)2009

    • Author(s)
      伊藤恭典、郡健二郎
    • Total Pages
      199-206
    • Publisher
      東京医学社

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Published: 2012-01-26   Modified: 2016-04-21  

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