Clinical and Genomic Risk Factors for Early Onset of Chronic Allograft Nephropathy

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591894
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Akita University
• Principal Investigator: SATOH Shigeru Akita University, 医学部, 教授 (80187195)
• Co-Investigator(Kenkyū-buntansha): MIURA Masatomo 秋田大学, 医学部, 准教授 (30265194) ; SAITO Mitsuru 秋田大学, 医学部, 助教 (80400505)
• Project Period (FY): 2008 – 2010
• Keywords: 腎移植

Research Abstract

The previously studies showed that the CYP3A5^*1 allele was associated with the early onset of acute rejection and tacrolimus-related chronic allograft nephropathy. In contrast to those reports, our results showed that the CYP3A5^*3/^*3 genotype was associated with subclinical acute rejection and increasing interstitial fibrosis within one year after transplantation.

Research Products

• [Journal Article] Factors Increasing Quantitative Interstitial Fibrosis from 0-hour to 1-year in Living Kidney Transplant Patients Receiving Tacrolimus. (2011)
  • Author(s): Miura Y, Satoh S, Saito M, Numakura K, Inoue T, Obara T, Tsuruta H, Narita S, Horikawa Y, Tsuchiya N, Komatsuda A, Kagaya H, Miura M, Habuchi T.
  • Journal Title: Transplantation 91 Pages: 78-85
  • Peer Reviewed
• [Journal Article] No impact of age on dose-adjusted pharmacokinetics of tacrolimus, mycophenolic acid and prednisolone 1 month after renal transplantation. (2009)
  • Author(s): Miura M, Satoh S, Kagaya H, Saito M, Inoue T, Tsuchiya N, Suzuki T, Habuchi T.
  • Journal Title: Eur J Clin Pharmacol 65 Pages: 1047-1053
  • Peer Reviewed
• [Journal Article] CYP3A5*1 allele associated with tacrolimus trough concentrations but not subclinical acute rejection or chronic allograft nephropathy in Japanese renal transplant recipients. (2009)
  • Author(s): Satoh S, Saito M, Inoue T, Kagaya H, Miura M, Inoue K, Komatsuda A, Tsuchiya N, Suzuki T, Habuchi T.
  • Journal Title: Eur J Clin Pharmacol 65 Pages: 473-481
  • Peer Reviewed
• [Journal Article] Lack of tacrolimus circadian pharmacokinetics and CYP3A5 pharmacogenetics in the early and maintenance stages in Japanese renal transplant recipients. (2008)
  • Author(s): Satoh S, Kagaya H, Saito M, Inoue T, Miura M, Inoue K, Tsuchiya N, Suzuki T, Habuchi T.
  • Journal Title: Brit J Clin Pharmacol 66 Pages: 207-214
  • Peer Reviewed
• [Presentation] Clinical risk factors for increased interstitial fibrosis by computerized image analysis after renal transplantation. (2010)
  • Author(s): Miura Y., Satoh S., Saito M., Numakura K., Tsuruta H., Obara T., Inoue T., Narita S., Horikawa Y., Tsuchiya N., Habuchi T.
  • Organizer: The 104th Annunal Meeting of the American Urological Association(Best of Posters Award.)
  • Place of Presentation: San Francisco.
  • Year and Date: 20100500-20100600
• [Presentation] Clinical risk factors for increased interstitial fibrosis by computerized image analysis after renal transplantation. (2010)
  • Author(s): Miura Y., Satoh S., Saito M., Numakura K., Narita S., Horikawa Y., Tsuchiya N., Habuchi T.
  • Organizer: The Annunal Meeting of the American Transplant Congress(Poster of Distinction.)
  • Place of Presentation: San Diego.
  • Year and Date: 20100500
• [Presentation] No impact of agen on dose-adjusted pharmacokinetics of tacrolimus, mycophenolic acid and prednisolone one month after renal transplantation. (2010)
  • Author(s): Satoh S., Saito M., Numakura K., Tsuruta H., Obara T., Inoue T., Narita S., Horikawa Y., Tsuchiya N., Habuchi T., Kagaya H., Miura M.
  • Organizer: The Annunal Meeting of the American Transplant Congress
  • Place of Presentation: San Diego.
  • Year and Date: 20100500
• [Presentation] Lack of tacrolimus circadian pharmacokinetics and CYP3A5 pahrmacogenetics in the early and maintenace stages in renal transplant recipients. (2009)
  • Author(s): Satoh S., Saito M., Kagaya H., Miura M., Inoue K., Miura Y., Numakura K., Kumazawa T., Tsuchiya N., Habuchi T.
  • Organizer: The Annunal Meeting of the American Transplant Congress
  • Place of Presentation: Boston
  • Year and Date: 20090500
• [Presentation] Influence of CYP3A5 polymorphism on tacrolimus trough concentrations and acute rejection or chronic allogaft nephropathy in renal transplant recipients. (2008)
  • Author(s): Shigeru Satoh, Mitsuru Saito, Takamitus Inoue, Hideaki Kagaya, Masatomo Miura, Kazuyuki Inoue, Tomonori Habuchi
  • Organizer: The Annunal Meeting of the American Transplant Congress
  • Place of Presentation: Tolonto, USA.
  • Year and Date: 20080531-20080604
• [Presentation] Clinical and genetic risk factors for posttransplant diabetes mellitus in adult renal transplant recipients treated with tacrolimus and mycophenolate mofetil. (2008)
  • Author(s): Shigeru Satoh, Kazuyuki Numakura, Mitsuru Saito, Takamitus Inoue, Kazuyuki Inoue, Masatomo Miura, Hideaki Kagaya, Hiroshi Tsuruta, Takashi Obara, Teruaki Kumazawa, Takeshi Yuasa, Norihiko Tsuchiya, Toshio Suzuki, Tomonori Habuchi
  • Organizer: The Annunal Meeting of the American Transplant Congress
  • Place of Presentation: Tolonto, USA
  • Year and Date: 20080531-20080604
• [Remarks] ホームページ等