2010 Fiscal Year Final Research Report
Analysis of genome maintenance of testicular stem cells in DNA deficient mice with impaired spermatogenesis.
| Project/Area Number |
20591898
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Tottori University |
|---|
Principal Investigator |
NAKANE Hironobu Tottori University, 医学部, 助教 (10304205)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | DNA修復欠損マウス / 精子形成 / 精巣幹細胞 |
|---|
| Research Abstract |
We have showed that xeroderma pigmentosum group A (Xpa) gene-knockout mice [Xpa (-/-) mice] provide a valuable model for growth retardation, internal tumor formation, impaired spermatogenesis as well as for UV-induced skin tumors in XPA patients. Gene expression analysis of each aged Xpa mice testis showed a different expression pattern of DNA repair gene, cell cycle-related gene(checkpoint), apoptosis-related gene compared to control. We found other pathological changes of the aged Xpa mice testis. These data will help us to understand the impaired spermatogenesis in the Xpa mice.
|
Research Products
(12 results)
