2010 Fiscal Year Final Research Report
Analysis of genome maintenance of testicular stem cells in DNA deficient mice with impaired spermatogenesis.
| Project/Area Number |
20591898
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Tottori University |
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Principal Investigator |
NAKANE Hironobu Tottori University, 医学部, 助教 (10304205)
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| Project Period (FY) |
2008 – 2010
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| Keywords | DNA修復欠損マウス / 精子形成 / 精巣幹細胞 |
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| Research Abstract |
We have showed that xeroderma pigmentosum group A (Xpa) gene-knockout mice [Xpa (-/-) mice] provide a valuable model for growth retardation, internal tumor formation, impaired spermatogenesis as well as for UV-induced skin tumors in XPA patients. Gene expression analysis of each aged Xpa mice testis showed a different expression pattern of DNA repair gene, cell cycle-related gene(checkpoint), apoptosis-related gene compared to control. We found other pathological changes of the aged Xpa mice testis. These data will help us to understand the impaired spermatogenesis in the Xpa mice.
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