2011 Fiscal Year Final Research Report
Development of new strategy for treatment of endometriosis with focus on the interaction of NEP and PTEN
| Project/Area Number |
20591912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagoya University |
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Principal Investigator |
IWASE Akira 名古屋大学, 医学部・附属病院, 講師 (20362246)
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Maki 名古屋大学, 医学部附属病院, 助教 (90378125)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 生殖医学 / 子宮内膜症 |
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| Research Abstract |
We found the expression of neutral endopeptidase(NEP), CD44(hyaluronan receptor) and PTEN in human endometrial stromal cells and endometriotic stromal cells. We also found that NEP is induced with progesterone. While the interaction of NEP and PTEN did not affect the signaling pathway of PI3K-Akt, NEP suppressed the CD44-dependent cell adhesion due to the inhibition of the interaction between CD44 and Ezrin/Radixin/Moesin(ERM) by NEP. The induction of NEP expression might lead to the development of the novel therapy of endometriosis.
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[Journal Article] Expression and localization of CXCL16 and CXCR6 in ovarian endometriotic tissues2011
Author(s)
Manabe S, Iwase A, Goto M, Kobayashi H, Takikawa S, Nagatomo Y, NakaharaT, Bayasula, Nakamura T, Hirokawa W, Kikkawa F
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Journal Title
Arch Gynecol Obstet
Volume: (in press)
Peer Reviewed
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