Studies on the pathogenesis of endometriosis and the development of novel medical treatment strategy

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20591920
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Oita University
• Principal Investigator: NASU Kaei Oita University, 医学部, 准教授 (30274757)
• Project Period (FY): 2008 – 2011
• Keywords: 子宮内膜症 / 病態 / 薬物療法 / 瘢痕化 / アポトーシス / エピジェネティクス

Research Abstract

子宮内膜症は全女性の3-10%に発生し、慢性骨盤痛、月経痛、性交痛や不妊などの症状を呈する。そのため子宮内膜症患者のquality of lifeは著しく低下する。
本研究は、(1)子宮内膜症と免疫異常、(2)子宮内膜症とapoptosisの異常、(3)子宮内膜症と瘢痕形成、(4)子宮内膜症とDNAメチル化異常の4つの観点から、子宮内膜症の病態の解明と新しい視点に基づく治療法の確立を目的として検討を行った。

Research Products

• [Journal Article] Aberrant expression of apoptosis-related molecules in endometriosis : a possible mechanism underlying the pathogenesis of endometriosis. (2011)
  • Author(s): Nasu K, Nishida M, Kawano Y, Tsuno A, Abe W, Yuge A, Takai N, Narahara H
  • Journal Title: Reprod Sci 18 Pages: 206-218
  • Peer Reviewed
• [Journal Article] Heparin is a promising agent for the treatment of endometriosis-associated fibrosis. (2010)
  • Author(s): Nasu K, Tsuno A, Hirao M, Kobayashi H, Yuge A, Narahara H.
  • Journal Title: Fertil Steril 94 Pages: 46-51
  • Peer Reviewed
• [Journal Article] Involvement of resistance to apoptosis in the pathogenesis of endometriosis. (2009)
  • Author(s): Nasu K, Yuge A, Tsuno A, Nishida M, Narahara H.
  • Journal Title: Histol Histopathol 24 Pages: 1181-1192
  • Peer Reviewed
• [Journal Article] Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells : a promising agent for the treatment of endometriosis. (2009)
  • Author(s): Nasu K, Yuge A, Tsuno A, Narahara H.
  • Journal Title: Fertil Steril 92 Pages: 2097-2099
  • Peer Reviewed
• [Journal Article] Decidualization attenuates the contractility of human eutopic and ectopic endometrial stromal cells : implications for hormone therapy of endometriosis. (2009)
  • Author(s): Tsuno A, Nasu K, Yuge A, Matsumoto H, Nishida M, Narahara H.
  • Journal Title: J Clin Endocrinol Metab 94 Pages: 2516-2523
  • Peer Reviewed
• [Presentation] 子宮内膜症細胞の細胞外マトリックスに対する接着性の増強 (2011)
  • Author(s): 奈須家栄, 他
  • Organizer: 第32回日本エンドメトリオーシス学会
  • Place of Presentation: 都市センターホテル
  • Year and Date: 20110122-20110123
• [Presentation] Mevalonate-Ras homology (Rho)/Rho-associated coiled-coil-forming protein kinase-mediated signaling pathway as a therapeutic target for the treatment of endometriosis-associated fibrosis. (2010)
  • Author(s): Nasu K.
  • Organizer: The First Asian Conference on Endometriosis
  • Place of Presentation: Shanghai Plaza Royale Hotel
  • Year and Date: 20101016-20101017
• [Presentation] 子宮内膜症の病態解明と新しい治療法の開発 (2010)
  • Author(s): 奈須家栄
  • Organizer: 第62回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 20100423-20100425
• [Presentation] Decidualization attenuates the contractility of endometriotic stromal cells. (2010)
  • Author(s): Nasu K., et al.
  • Organizer: 2010 Society for Gynecologic Investigation 57th Annual Meeting
  • Place of Presentation: Orlando World Center Marriott Resort
  • Year and Date: 20100324-20100327
• [Presentation] 子宮内膜症の瘢痕化に対するジェノゲストの効果-脱落膜化との関連- (2009)
  • Author(s): 奈須家栄, 他
  • Organizer: 第30回日本エンドメトリオーシス学会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 20090117-20090118
• [Book] Aromatase Inhibitors : Types, Mode of Action and Indications. (2010)
  • Author(s): Nasu K, Tsuno A, Yuge A, Nishida M, Narahara H.
  • Total Pages: 95-111
  • Publisher: Nova Science Publishers Inc.
• [Book] Endometriosis : Symptoms, Diagnosis and Treatments. (2010)
  • Author(s): Nasu K, Tsuno A, Yuge A, Kawano Y, Narahara H.
  • Total Pages: 197-212
  • Publisher: Nova Science Publishers Inc.
• [Book] Cell Movement : New Research Trends. (2009)
  • Author(s): Nasu K, Yuge A, Matsumoto H, Tsuno A, Narahara H.
  • Total Pages: 247-263
  • Publisher: Nova Science Publishers Inc.