Study for the investigation of etiology of polycystic ovary syndrome (PCOS) using androgen-treated female to male transsexuals as a PCOS model

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591922
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Sapporo Medical University
• Principal Investigator: ENDO Toshiaki Sapporo Medical University, 医学部, 准教授 (90213595)
• Project Period (FY): 2008 – 2010
• Keywords: 性同一性障害 / 男性ホルモン / 多嚢胞卵巣症候群 / インスリン抵抗性 / adiponectin

Research Abstract

Androgen exposure mechanism is one of major candidates for the etiology of polycystic ovary syndrome (PCOS). We examined the effects of androgen treatment on female to male transsexuals as a model of PCOS. We got the results that androgen induced secondary PCOS endocrinologically and histologically, even partially. It is suspected that androgen exposure is one of etiology for PCOS.

Research Products

• [Journal Article] Distinktive features of female-to-male transsexualism and prevalence of gender indentity disorder in Japan. (2011)
  • Author(s): Baba T, Endo T, Ikeda K, Shimizu A, Honnma H, Ikeda H, Masumori N, Ohmura T, Kiya T, Fujimoto T, Koizumi M, Saito T
  • Journal Title: J Sex Med (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Remarkable features of ovarian morphology and reproductive hormones in insulin-resistant Zucker fatty (fa/fa) rats. (2010)
  • Author(s): Honnma H, Endo T, Kiya T,Shimizu A, Nagasawa K, Baba T, Fujimoto T, Henmi H, Kitajima Y, Manase K, Ishioka S, Ito E, Saito T.
  • Journal Title: Reprod Biol Endocrinol 8(電子ジャーナル) Pages: 73
  • Peer Reviewed
• [Journal Article] Cohort Profile : The Hokkaido Study on Environment and Children's Health in Japan. (2010)
  • Author(s): Kishi R, Sasaki S, Yoshioka E, Yuasa M, Sata F, Saijo Y, Kurahashi Y, Tamaki J, Endo T, Sengoku K, Nonomura K, Minakami H, or the Hokkaido Study on Environment and Children's Health.
  • Journal Title: International Journal of Epidemiology in press
  • Peer Reviewed
• [Journal Article] The contributions of resistin and adiponectin gene single nucleotide polymorphisms to the genetic risk for polycystic ovary syndrome in a Japanese population. (2009)
  • Author(s): Baba T, Endo T, Sata F, Nagasawa K, Honnma H, Kitajima Y, Hayashi T, Manase K, Kanaya M, Moriwaka O, Kamiya H, Yamada H, Minakami H, Kishi R, Saito T.
  • Journal Title: Gynecol Endocrinol 25 Pages: 498-503
  • Peer Reviewed
• [Journal Article] Spontaneous ovarian hyperstimulation syndrome and pituitary adenoma : incidental pregnancy triggers a catastrophic even Fertil Steril. (2009)
  • Author(s): Baba T, Endo T, Kitajima Y, Kamiya H, Moriwaka O, Saito T.
  • Journal Title: 92 Pages: 390.e1-390.e3
  • Peer Reviewed