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2010 Fiscal Year Final Research Report

The study for the nutritional management of endothelial dysfunction seen in pregnancy-induced hypertension

Research Project

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Project/Area Number 20591926
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNagoya City University

Principal Investigator

SUZUKI Yoshikatsu  Nagoya City University, 大学院・医学研究科, 研究員 (30254288)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Tamao  名古屋市立大学, 大学院・医学研究科, 研究員 (20405210)
ITOH Takeo  名古屋市立大学, 大学院・医学研究科, 教授 (70159888)
Project Period (FY) 2008 – 2010
Keywords妊娠高血圧症候群 / 血管内皮機能 / L-アルギニン / 葉酸 / 発症予知 / 予防
Research Abstract

Preeclampsia causes to increase vascular tone and permeability due to the activation of endothelial function. In the present study, we investigated whether an oral supplementation of L-arginine plus folic acid could improve it and prevent from developing preeclampsia. The concentration of L-arginine in RBC had been increasing in normal pregnant women, while it was reduced in preeclamptic women. Flow mediate vasodilatation (FMD), non-invasive evaluation of endothelial function using ultrasound was reduced in high risk women at early pregnancy. The reduction could be improved by the contentious administration of L-arginine 1g plus folic acid 0.8mg/day from the second trimester. In conclusion, the supplementation of L-arginine plus folic acid might improve the endothelial dysfunction seen in high risk group and prevent onset of preeclampsia.

  • Research Products

    (11 results)

All 2011 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Book (3 results)

  • [Journal Article] Glycogen storage disease type Ia (GSD Ia) during pregnancy : Report of a case complicated by fetal growth restriction and preeclampsia.2010

    • Author(s)
      Yamamoto T, Suzuki Y, Kaneko S, Hattori Y, Obayashi S, Suzumori N, Sugiura M.
    • Journal Title

      J Obstet Gynaecol Res. 36

      Pages: 1125-1129

    • Peer Reviewed
  • [Journal Article] The Biological investigation of prostacyclin in preeclamptic women seen reduced endothelial function.2010

    • Author(s)
      Yamamoto T, Suzuki Y, Kojima K, Suzumori N, Suzuki T.
    • Journal Title

      Hypertens Pregnancy. 29

      Pages: 484-491

    • Peer Reviewed
  • [Journal Article] 妊娠高血圧症候群-発症予知・予防は可能か-2010

    • Author(s)
      鈴木佳克、山本珠生、伊藤猛雄
    • Journal Title

      産婦人科の実際 59

      Pages: 335-340

  • [Journal Article] Establishment of a polymerase chain reaction method for detection of Escherichia coli in amniotic fluid in patients with chorioamnionitis.2008

    • Author(s)
      Daoud GA, Suzuki Y, Yamamoto T, Suzuki T, Suzumori N, Tanemura M.
    • Journal Title

      Fetal Diagn Ther. 24

      Pages: 132-139

    • Peer Reviewed
  • [Presentation] Does supplementation of L-arginine plus folic acid improve reduced endothelial function seen in preeclampsia?2009

    • Author(s)
      Suzuki Y, Yamamoto T, Itoh T
    • Organizer
      Society for Gynecologic Investigation 3rd International Summit
    • Place of Presentation
      Sendai
    • Year and Date
      20091112-20091114
  • [Presentation] ワークショップ「葉酸+L-アルギニンサプリメントは妊娠高血圧腎症の発症予防に有効か?」2009

    • Author(s)
      鈴木佳克、山本珠生、鈴森伸宏
    • Organizer
      第45回日本周産期・新生児医学会
    • Place of Presentation
      名古屋
    • Year and Date
      20090712-20090714
  • [Presentation] There might be two types of preeclampsia with and without on placental disorders2008

    • Author(s)
      Suzuki Y, Yamamoto T, Sugiura M, Watanabe Y, Itoh T
    • Organizer
      XVI World congress of the international society for the Study of Hypertension in Pregnancy
    • Place of Presentation
      Washington DC
    • Year and Date
      20080921-20090924
  • [Presentation] The supplementation of L-arginine plus folic acid in high risk pregnant women of preeclampsia2008

    • Author(s)
      Yamamoto T, Suzuki Y, Sugiura M, Watanabe Y
    • Organizer
      XVI World congress of the international society for the Study of Hypertension in Pregnancy
    • Place of Presentation
      Washington DC
    • Year and Date
      20080921-20080924
  • [Book] よくわかる妊娠高血圧症候群Q&A-新基準のガイダンス-(日本妊娠高血圧学会編)2011

    • Author(s)
      鈴木佳克
    • Publisher
      金原出版
  • [Book] 妊娠高血圧症候群関連疾患、(「必携ハイリスク妊娠の診療を極める」)(江口勝人編)2009

    • Author(s)
      鈴木佳克、山本珠生
    • Total Pages
      179-185
    • Publisher
      永井書店
  • [Book] 妊娠高血圧症候群(PIH)管理ガイドライン2009(日本妊娠高血圧学会編)2009

    • Author(s)
      鈴木佳克
    • Publisher
      メジカルビュー社

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Published: 2012-01-26   Modified: 2016-04-21  

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