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2010 Fiscal Year Final Research Report

Evaluation of the role of self-reactive T cells in liver dysfunction during pregnancy

Research Project

  • PDF
Project/Area Number 20591932
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNippon Medical School

Principal Investigator

ICHIKAWA Masao  日本医科大学, 医学部, 助教 (20366660)

Co-Investigator(Kenkyū-buntansha) TAKESHITA Toshiyuki  日本医科大学, 大学院・医学研究科, 教授 (60188175)
SATOMI Misao  日本医科大学, 医学部, 助教 (80318500)
Project Period (FY) 2008 – 2010
Keywords産科学
Research Abstract

In the liver of the B7-H1 knockout mouse, PD-1poitive T cell had accumulated and have potential to cause liver damage. However, those cells did not change the number during the pregnancy and did not seem to be associated with the liver damage. On the other hand, B7-H1 molecules on the placenta in mouse model could play a role in feto-maternal tolerance, because the group which was administered with anti-B7-H1 blocking antibody and anti-4-1BB antibody shows miscarriage in 22.2% compared with the control in 4.1%.

  • Research Products

    (2 results)

All 2010 2009

All Journal Article (1 results) Presentation (1 results)

  • [Journal Article] 妊娠とB7-H12010

    • Author(s)
      市川雅男
    • Journal Title

      医学の歩み

      Volume: Vol.233 No.2 Pages: 151-155

  • [Presentation] 妊娠とB7-H1分子(B7-H1knockout mouseのPhenotypeの解析を中心に)2009

    • Author(s)
      市川雅男
    • Organizer
      日本生殖免疫学会
    • Place of Presentation
      東京
    • Year and Date
      20091100

URL: 

Published: 2013-07-31  

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