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2010 Fiscal Year Final Research Report

Study for improving the diagnosis of polycystic ovary syndrome

Research Project

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Project/Area Number 20591951
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionThe University of Tokushima

Principal Investigator

IRAHARA Minoru  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (20160070)

Co-Investigator(Kenkyū-buntansha) MATUZAKI Toshiya  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (70294692)
Project Period (FY) 2008 – 2010
Keywords多嚢胞性卵巣症候群 / PCOS / LH / LH / FSH比 / 診断基準 / エクルーシス / テストステロン / アンドロゲン
Research Abstract

We studied appropriate method to estimate hormonal findings for the diagnosis of polycystic ovary syndrome (PCOS). Timing of measurement of serum LH is later than 10 days from withdrawal bleeding. LH/FSH rate is better than LH level in obese PCOS patients. We determined the cut of values of LH, LH/FSH ratio and testosteron (T) for the diagnosis of PCOS. T assay has become necessary for the diagnosis of PCOS also in Japan due to recent advance of T. Results of this study would be contribute for better diagnosis of Japanese PCOS patients.

  • Research Products

    (33 results)

All 2011 2010 2009 2008

All Journal Article (20 results) (of which Peer Reviewed: 2 results) Presentation (7 results) Book (6 results)

  • [Journal Article] (the 10th out of 10) Neuropeptide Y mediates orexin A-mediated suppression of pulsatile gonadotropin-releasing hormone secretion in ovariectomized rats.2011

    • Author(s)
      Kiyokawa M, Matsuzaki T, Irahara M, et al.
    • Journal Title

      J Med Invest. 58(1-2)Peer-Reviewed

      Pages: 11-18

  • [Journal Article] (the 9th out of 9) Sensitivities of mRNA expression levels of Kissl and itsreceptor, Kisslr, to nutritional status are changed during the developmental period in female rats.2010

    • Author(s)
      Iwasa T, Matsuzaki T, Irahara M, et al.
    • Journal Title

      J Endocrinol. 207(2)Peer-Reviewed

      Pages: 195-202

  • [Journal Article] プロラクチン2010

    • Author(s)
      松崎利也、苛原稔, 他3名
    • Journal Title

      産婦人科検査マニュアル(診断と治療社、東京) Vol.77,Suppl

      Pages: 121-127

  • [Journal Article] エクルーシス試薬テストステロンII, LH, FSHの基準値の検討2010

    • Author(s)
      木内理世、松崎利也、岩佐武、三室卓久、苛原稔
    • Journal Title

      医学と薬学 64

      Pages: 87-93

  • [Journal Article] 不妊治療と多嚢胞性卵巣症候群2010

    • Author(s)
      苛原稔、松崎利也、岩佐武、桑原章
    • Journal Title

      産婦人科の実際 59

      Pages: 705-710

  • [Journal Article] (the 9th out of 9) Effects of intrauterine undernutrition on hypothalamic Kissl expression and the timing of puberty in female rats.2010

    • Author(s)
      Iwasa T, Matsuzaki T, Irahara M, et al.
    • Journal Title

      J Physiol. 588(Pt5)Peer-Reviewed

      Pages: 821-829

  • [Journal Article] (the 9th out of 9) Neonatal LPS injection alters the body weight regulation systems of rats under non-stress and immune stress conditions.2010

    • Author(s)
      Iwasa T, Matsuzaki T, Irahara M, et al.
    • Journal Title

      Int J Dev Neurosci. 28(1)Peer-Reviewed

      Pages: 119-124

  • [Journal Article] 続発性無月経と高プロラクチン血症を呈したマクロプロラクチン血症の1例2009

    • Author(s)
      清川麻知子、松崎利也、苛原稔, 他5名
    • Journal Title

      現代産婦人科 Vol.58, No.,2

      Pages: 171-175

    • Peer Reviewed
  • [Journal Article] 胚盤胞を用いた単一胚移植で発生した一絨毛膜性二羊膜性双胎の検討2009

    • Author(s)
      清川麻知子、松崎利也、苛原稔, 他9名
    • Journal Title

      現代産婦人科 Vol.58, No.2

      Pages: 255-259

    • Peer Reviewed
  • [Journal Article] (the 8th out of 8) Hypothalamic Ghrelin suppresses pulsatile secretion of luteinizing hormone viabeta-endorphin in ovariectomized rats.2009

    • Author(s)
      Ogata R, Matsuzaki T, Irahara M, et al.
    • Journal Title

      Neuroendocrinology. 90(4)Peer-Reviewed

      Pages: 364-70

  • [Journal Article] (the 8th out of 8) Neonatal immune challenge affects the regulation of estrus cyclicity and feeding behavior in female rats.2009

    • Author(s)
      Iwasa T, Matsuzaki T, Irahara M, et al.
    • Journal Title

      Int.J.Dev Neurosci. 27(1)Peer-Reviewed

      Pages: 111-114

  • [Journal Article] (the 7th out of 7) Reproducibility of luteinizing hormone hypersecretion in different phases of the menstrual cycle in polycystic ovary syndrome.2009

    • Author(s)
      Iwasa T, Matsuzaki T, Irahara M, et al.
    • Journal Title

      J Obstet Gynaecol Res. 35(3)Peer-Reviewed

      Pages: 514-519

  • [Journal Article] (the 8th out of 8) Neonatal lipopolysaccharide exposure attenuates the homotypic stress-induced suppression of LH secretion in adulthood in male rat.2009

    • Author(s)
      Iwasa T, Matsuzaki T, Irahara M, et al.
    • Journal Title

      Int.J.Dev Neurosci. 27(4)Peer-Reviewed

      Pages: 345-349

  • [Journal Article] やせと生殖内分泌障害の病態2009

    • Author(s)
      苛原稔、松崎利也, 他3名
    • Journal Title

      Pharma Media Vol.27 No.10

      Pages: 41-44

  • [Journal Article] 女性とメタボリックシンドローム 第3回メタボリックシンドロームとしてのPCOS2008

    • Author(s)
      苛原稔、松崎利也
    • Journal Title

      Reproductive Medicine 32

      Pages: 2-3

  • [Journal Article] 5) PCOSの新しい診断基準2008

    • Author(s)
      苛原稔
    • Journal Title

      日本産科婦人科学会雑誌 60

      Pages: 185-190

  • [Journal Article] (the 5^<th> out of 7) Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats.2008

    • Author(s)
      Murakami M, Matsuzaki T, Irahara M, et al.
    • Journal Title

      J Endocrinol. 199(1)Peer-Reviewed

      Pages: 105-112

  • [Journal Article] (the 7th out of 7) Decreased expression of kisspeptin mediated acute immune/inflammatory stress-induced suppression of gonadotropin secretion in female rat.2008

    • Author(s)
      Iwasa T, Matsuzaki T, Irahara M, et al.
    • Journal Title

      J Endocrinol Invest. 31(7)Peer-Reviewed

      Pages: 656-659

  • [Journal Article] (the 9th out of 9) Estradiol suppresses NMU mRNA expression during sexual maturation in the female rat pituitary.2008

    • Author(s)
      Shimizu F, Matsuzaki T, Irahara M, et al.
    • Journal Title

      Int J Devl Neuroscience. 26(3-4)Peer-Reviewed

      Pages: 381-384

  • [Journal Article] (the 9th out of 9) Transition of leptin receptor expression during pubertal development in female rat pituitary.2008

    • Author(s)
      Shimizu F, Matsuzaki T, Irahara M, et al.
    • Journal Title

      Endocrine Journal 55(1)Peer-Reviewed

      Pages: 191-198.

  • [Presentation] (the 6th out of 6) Effects of Intra-Uterine Undernutrition on Hypothalamic Kissl Expression and the Timing of Puberty in Female Rats.2010

    • Author(s)
      Iwasa T, Matsuzaki T, Irahara M, et al.
    • Organizer
      The Endocrine Society's 92^<th> Annual Meeting
    • Place of Presentation
      San Diego, CA, USA.
    • Year and Date
      20100619-20100622
  • [Presentation] Complications in laparoscopy.2010

    • Author(s)
      Minoru Irahara.
    • Organizer
      IFFS 20^<th> World Congress on Fertility & Sterility Munich
    • Place of Presentation
      Germany
    • Year and Date
      2010-09-12
  • [Presentation] 多嚢胞性卵巣症候群の診断と治療Update2010

    • Author(s)
      苛原稔
    • Organizer
      第122回近畿産婦人科学会総会ならびに学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2010-06-20
  • [Presentation] New Criteria of polycystic ovary syndrome in Japan.2010

    • Author(s)
      Minoru Irahara.
    • Organizer
      Polycystic ovary syndrome 14^<th> International congress of endocrinology.
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-03-28
  • [Presentation] Physiological roles of cytokines in ovulation and follicular atresia.2009

    • Author(s)
      Irahara M.
    • Organizer
      International congress on Bio-immunoregulatorymechanisms associated with reproductive organs : relevance in fertility and in sexually transmitted infections.
    • Place of Presentation
      New Delhi, India
    • Year and Date
      20090209-20090213
  • [Presentation] Assessment of serum LH and androgen levels for the diagnosis of polycystic ovary syndrome in Japan.2009

    • Author(s)
      Irahara M.
    • Organizer
      First International Asia pacific meeting on polycystic ovary syndrome.
    • Place of Presentation
      Hong Kong
    • Year and Date
      20090117-20090118
  • [Presentation] (the 6th out of 6) Assessment of serum LH level and LH/FSH ratio using electrochemistry luminescence immunoassay method for the diagnosis of porycystic ovarysyndrome2009

    • Author(s)
      Matsuzaki T, Irahara M, et al.
    • Organizer
      The International Ovarian Conference 2009.
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-12-05
  • [Book] 今日の診断指針第6版(金澤一郎、永井良造総集編)(月経異常・排卵障害)2010

    • Author(s)
      松崎利也
    • Total Pages
      423-425
    • Publisher
      医学書院、東京
  • [Book] 下垂体腫瘍のすべて(ゴナドトロピン系)2009

    • Author(s)
      苛原稔
    • Total Pages
      46-51
    • Publisher
      医学書院
  • [Book] インフォームドコンセントのための図説シリーズ不妊症・不育症 改訂版2009

    • Author(s)
      苛原稔
    • Total Pages
      6-11
    • Publisher
      医薬ジャーナル社
  • [Book] -薬剤選択と処方のポイント-(女性ホルモン剤 治療薬ハンドブック2008)2008

    • Author(s)
      苛原稔
    • Total Pages
      623-629
  • [Book] -薬剤選択と処方のポイント-(その他のホルモン剤-排卵誘発治 療治療薬ハンドブック2008)2008

    • Author(s)
      苛原稔
    • Total Pages
      645-649
  • [Book] 不妊症-臨床と研究の最前線(無排卵に対する排卵誘発 第1章排卵障害 別冊・医学のあゆみ)2008

    • Author(s)
      苛原稔
    • Total Pages
      5-10

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Published: 2012-01-26   Modified: 2016-04-21  

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