A made-to-order ovarian cancer treatment strategy using thalidomide as the newly molecular target antineoplastic drug

2010 Fiscal Year Final Research Report

• Project/Area Number: 20591957
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Nara Medical University
• Principal Investigator: YAMADA Yoshihiko Nara Medical University, 医学部, 講師 (80275346)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Hiroshi 奈良県立医科大学, 医学部, 教授 (40178330)
• Project Period (FY): 2008 – 2010
• Keywords: 卵巣がん / 分子標的抗腫瘍薬 / 浸潤 / アノイキス / マイクロアレイ

Research Abstract

We were going to search for the antitumor material which resembled thalidomide by analyzing a function of HNF-1beta which specifically developed in the clear cell adenocarcinoma which was intractable ovarian cancer high. HNF-1beta was proved to be involved in the invasion ability of the tumor, antiapoptosis and anticancer drug resistance. Furthermore, we analyzed a function of HNF-1beta about the cell cycle. As a result, because HNF-1beta made a phosphorylation of chk1 persist, we caused the activation of the persistent checkpoint of the cancer cell, and it became clear that it was with one of the factors that were the carcinostatic of the ovary clear cell adenocarcinoma-resistant in its turn. It is said that most of cancer cells depend on the G2/M checkpoint for DNA repair, and it is thought that it may be with the target of the new drug for the ovarian clear cell adenocarcinoma in chk1 involved in the G2/M checkpoint.

Research Products

• [Journal Article] New insights into the pathophysiology of endometriosis : from chronic inflammation to danger signal. (2011)
  • Author(s): Kajihara H, Yamada Y, Kanayama S, Furukawa N, Noguchi T, Haruta S, Yoshida S, Sado T, Oi H, Kobayashi H.
  • Journal Title: Gynecol Endocrinol. 27 Pages: 73-79
  • Peer Reviewed
• [Journal Article] New insights into pattern recognition receptors and their ligands in gynecologic pathologies. (2011)
  • Author(s): Yamada Y, Shigetomi H, Onogi A, Haruta S, Kawaguchi R, Yoshida S, Furukawa N, Nagai A, Tanase Y, Tsunemi T, Oi H, Kobayashi H.
  • Journal Title: Hum Immunol. 72 Pages: 213-218
  • Peer Reviewed
• [Journal Article] Clear cell carcinoma of the ovary : potential pathogenic mechanisms. (2010)
  • Author(s): Kajihara H, Yamada Y, Kanayama S, Furukawa N, Noguchi T, Haruta S, Yoshida S, Sado T, Oi H, Kobayashi H.
  • Journal Title: Oncol Rep. 23 Pages: 1193-1203
  • Peer Reviewed
• [Journal Article] Theoretical model of treatment strategies for clear cell carcinoma of the ovary : focus on perspectives. (2009)
  • Author(s): Yoshida S, Furukawa N, Haruta S, Tanase Y, Kanayama S, Noguchi T, Sakata M, Yamada Y, Oi H, Kobayashi H.
  • Journal Title: Cancer Treat Rev. 35 Pages: 608-615
  • Peer Reviewed
• [Journal Article] Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review). (2009)
  • Author(s): Kobayashi H, Kajiwara H, Kanayama S, Yamada Y, Furukawa N, Noguchi T, Haruta S, Yoshida S, Sakata M, Sado T, Oi H.
  • Journal Title: Oncol Rep. 22 Pages: 233-240
  • Peer Reviewed
• [Journal Article] The role of hepatocyte nuclear factor-1beta in the pathogenesis of clear cell carcinoma of the ovary. (2009)
  • Author(s): Kobayashi H, Yamada Y, Kanayama S, Furukawa N, Noguchi T, Haruta S,Yoshida S, Sakata M, Sado T, Oi H.
  • Journal Title: Int J Gynecol Cancer. 19 Pages: 471-479
  • Peer Reviewed
• [Presentation] Investigation into the biological functions of Hepatocyte Nuclear Factor-1 beta in the clear cell adenocarcinoma of ovary. (2010)
  • Author(s): 重富洋志, 山田嘉彦, 小林浩, et al.
  • Organizer: The First Asia Conference on Endometriosis.
  • Place of Presentation: Shanghai
  • Year and Date: 20101015-20101017
• [Presentation] 卵巣明細胞腺癌における転写因子HNF-1betaのターゲット遺伝子の網羅的検索 (2010)
  • Author(s): 重富洋志、山田嘉彦、小林浩
  • Organizer: 第19回日本がん転移学会
  • Place of Presentation: 金沢
  • Year and Date: 20100616-20100617
• [Presentation] 卵巣明細胞腺癌におけるHepatocyte nuclear factor-1 beta発現の生物学的意義 (2009)
  • Author(s): 山田嘉彦、小林浩, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] 卵巣明細胞腺癌におけるHepatocyte nuclear factor-1 beta発現の生物学的意義 (2009)
  • Author(s): 山田嘉彦、小林浩, 他
  • Organizer: 第61回日本産科婦人科学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-04-03