2011 Fiscal Year Final Research Report
Analysis of A Role of IGF-1 and Its Associated Molecules in Cervical Carcinogenesis Using Animal Models(Transgenic Mice)
| Project/Area Number |
20591966
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | 国立病院機構四国がんセンター (2011)
Department of Clinical Research, National Hospital Organization Shikoku Cancer Center (2008-2010) |
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Principal Investigator |
MATSUMOTO Takashi 国立病院機構四国がんセンター, 臨床研究センター・がん診断治療開発部・がん治療開発室, 室長 (20346670)
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| Co-Investigator(Kenkyū-buntansha) |
IGUCHI Haruo 国立病院機構四国がんセンター, 臨床研究センター, センタ-長 (90393438)
SUGITA Atsuro 愛媛大学, 医学部附属病院, 准教授 (60179140)
UEDA Norifumi 愛媛大学, 医学研究科, 教授 (30030886)
WROBLEWSKI Junko 国立病院機構四国がんセンター, 臨床研究部, 医師 (80463488)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 子宮頸癌 / 動物モデル / トランスジェニックマウス / 腫瘍発生 / IGF-1 |
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| Research Abstract |
Serum levels of IGF-1 have been identified as risk factors for cervical cancer. In this study, we generated transgenic(Tg) mice that overexpressed an IGF-1 in uterine cervix. IGF-1 Tg mice developed cervical intraepithelial neoplasia(20% incidence). Furthermore, we examined the impact of loss of tumor suppressor genes associated with cervical carcinogenesis on IGF-1-mediated tumor promotion in uterine cervix of IGF-1 Tg mice. IGF-1 Tg mice deficient in PTEN and Bax were more sensitive to tumor promotion of uterine cervix, and p53 deficiency cooperates with increased IGF-1 signaling to drive tumor progression.
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