2010 Fiscal Year Final Research Report
Study for mechanisms and treatments of cochlear injury induced by ototoxic agents
| Project/Area Number |
20591969
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
TABUCHI Keiji University of Tsukuba, 大学院・人間総合科学研究科, 講師 (80361335)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 蝸牛 / ゲンタマイシン / neurosteroid |
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| Research Abstract |
Protective effects of nerustroids including estrogens on cochlear injury induced by ototoxic agents were reported. Estrogens protected the cochlea via c-jun-N-terminal kinase pathway. Dehydroepiandrosterone exhibited the protective effects against aminoglycoside ototoxicity. Protective effects of gagliosides and sphingosine-1-phosphate were also reported. However, ceramide exacerbated the cochlear injury induced by animoglycosides.
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