2010 Fiscal Year Final Research Report
Investigation of pathology of age-related hearing loss and noise-induced hearing loss and application for treatment using gene modification animals
| Project/Area Number |
20591979
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nagoya University |
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Principal Investigator |
TERANISHI Masaaki Nagoya University, 医学系研究科, 講師 (20335037)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Tsutomu 名古屋大学, 大学院・医学系研究科, 教授 (30180277)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 蝸牛 / 加齢 / シグナル伝達 / 培養 |
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| Research Abstract |
The C57BL/6 mouse is used as animal models of the sensorineural deafness by the aging widely. We show the expression of oxidative stress marker reinforcement of the nucleic acid with aging, and oxidative stress is considered to increase. Proteomics analysis revealed the decrease of mitochondria-related proteins and antioxidant enzymes. Using organ culture of the inner ear, we established a method to evaluate signal transduction after the growth factors administration by immunohistochemistry.
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Research Products
(28 results)
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[Journal Article] Association of interleukin-1 gene polymorphisms with sudden sensorineural hearing loss and Meniere's disease.2011
Author(s)
Furuta T, Teranishi M, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Tagaya M, Suzuki H, Sugiura M, Sone M, Hiramatsu M, Sugiura S, Ando F, Shimokata H, Nakashima T
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Journal Title
Int J Immunogenet in press
Peer Reviewed
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[Journal Article] Relationship between the Degree of Endolymphatic Hydrops and Electrocochleography.2010
Author(s)
Yamamoto M, Teranishi M, Naganawa S, Otake H, Sugiura M, Iwata T, Yoshida T, Katayama N, Nakata S, Sone M, Nakashima T
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Journal Title
Audiol Neurootol 15
Pages: 254-260
Peer Reviewed
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[Journal Article] 3D computerized model of endolymphatic hydrops from specimens of temporal bone.2009
Author(s)
Teranishi M., Yoshida, T., Katayama, N., Hayashi, H., Otake, H., Nakata, S., Sone, M., Schachern, P.A., Paparella, M.M., Nakashima T.
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Journal Title
Acta Otolaryngol Suppl 560
Pages: 43-47
Peer Reviewed
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[Journal Article] Endolymphatic space imaging in patients with delayed endolymphatic hydrops.2009
Author(s)
Kasai, S., Teranishi M., Katayama, N., Sugiura,M., Nakata, S., Sone, M., Naganawa, S., Nakashima T.
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Journal Title
Acta Otolaryngol 129
Pages: 1169-1174
Peer Reviewed
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[Presentation] 突発性難聴とメニエール病におけるインターロイキン1遺伝子多型の関連2010
Author(s)
古田敏章, 杉浦真, 平松真理子, 寺西正明, 加藤健, 鈴木秀典, 大竹宏直, 吉田忠雄, 鈴木宏和, 曾根三千彦, 中島務, 内田育恵, 杉浦彩子, 安藤富士子, 下方浩史, 西尾直樹, 多賀谷満彦
Organizer
第143回東海地方部会連合講演会
Place of Presentation
岐阜
Year and Date
2010-12-12
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[Presentation] 3D-Computer model of endolymphatic hydrops.2008
Author(s)
Teranishi M., Yoshida T., Katayama N., Hayashi, H., Otake H., Nakata, S., Sone M., Nakashima T.
Organizer
45th Inner Ear Biology Workshop
Place of Presentation
Ferrara, Italy
Year and Date
20080921-20080924
