2011 Fiscal Year Final Research Report
Visualizing and dynamic analysis of spiral ganglion cell progenitors b using of human hearing-loss model animals
| Project/Area Number |
20591980
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyoto University |
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Principal Investigator |
KOJIMA Ken 京都大学, 医学研究科, 客員研究員 (60378685)
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| Co-Investigator(Kenkyū-buntansha) |
OUTSUKA Toshiyuki 京都大学, ウイルス研究所, 准教授 (20324709)
IKEDA Katsuhisa 順天堂大学, 医学部, 教授 (70159614)
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| Project Period (FY) |
2008 – 2011
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| Keywords | らせん神経節細胞 / 前駆細胞 / 衛星細胞 / lineage tracing / 難聴モデル動物 / in vivo / in vitro |
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| Research Abstract |
Stem cell marker protein expressing cells identified by use of transgenic animals were analyzed in vivo and in vitro. In spite of different lineage from spiral ganglion neurons, satellite cells expressing stem cell markers in spiral ganglion were induced to neural phenotypes in vitro. In vivo analyses showed that no satellite cell were induced to neural phenotypes. These results indicated that some kinds of controls of proliferation and differentiation of the satellite cells were needed for regeneration of spiral ganglion neurons in vivo.
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[Journal Article] Mechanical stress-induced reactive gliosis in the auditory nerve and cochlear nucleus2010
Author(s)
Sekiya T, Matsumoto M, Kojima K, Ono K, Kikkawa YS, Kada S, Ogita H, Horie RT, ViolaA, Holley MC, Ito J
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Journal Title
J Neurosurg
Volume: 114(2)
Pages: 414-25
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