2010 Fiscal Year Final Research Report
Vestibular plasticity-a role of vestibular ganglion-
| Project/Area Number |
20591984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SHIMOGORI Hiroaki Yamaguchi University, 大学院・医学系研究科, 准教授 (70226273)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 前庭神経系 / 前庭神経節 / CREB / 抗うつ薬 |
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| Research Abstract |
I evaluated patterns of p-CREB induction in guinea pig vestibular ganglion cells after various kinds of vestibular disorders. In each model, p-CREB had disappeared within 8 hours after disorder. On the basis of this fact, I found that direct inner ear infusion of rolipram, one of antidepressants, induced p-CREB up-regulation in vestibular ganglion cells. While, rolipram also induced some damage on vestibular ganglion cells morphologically. Next, amitriptyline, a tricyclic antidepressant, was applied systemically to guinea pig with vestibular disorder, and facilitated vestibular functional recovery.
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Research Products
(18 results)
