2010 Fiscal Year Final Research Report
Cochlear hair cell regeneration by re-activation of cell cycle of the supporting cells
| Project/Area Number |
20591989
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kumamoto University |
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Principal Investigator |
MINODA Ryosei Kumamoto University, 大学院・生命科学研究部, 准教授 (30284772)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 再生 / 内耳 |
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| Research Abstract |
P27^<kip1> has a function to suppress the proliferation of supporting cell in the adult mammal cochlea. Considering this, downregulation of P27^<kip1> in adult mammal cochlea may cause proliferation of the supporting cells.
P27^<kip1> existed in supporting cells in normal mouse organ of Corti. P27^<kip1> downregulation utilizing siRNA for P27^<kip1> resulted in re-entry into cell cycle of the supporting cells and proliferation of the supporting cells. Nevertheless, those supporting cells did not show phenotype of cochlear hair cells.
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