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2010 Fiscal Year Final Research Report

Molecular pathogenesis of middle ear mucosal proliferation during bacterial otitis media

Research Project

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Project/Area Number 20591992
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionJuntendo University

Principal Investigator

FURUKAWA Masayuki  Juntendo University, 医学部, 准教授 (20359524)

Co-Investigator(Kenkyū-buntansha) IKEDA Katuhisa  順天堂大学, 医学部, 教授 (70159614)
KUSUNOKI Takeshi  順天堂大学, 医学部, 准教授 (30248025)
YOKOI Hidenori  順天堂大学, 医学部, 准教授 (80317487)
Project Period (FY) 2008 – 2010
KeywordsDNA microarray / 中耳粘膜肥厚 / 中耳炎
Research Abstract

We used gene array to assess gene expression in the mouse middle ear in the first 24h following exposure to Haemophilus influenzae. We observed 513 transcripts that were significantly up-regulated 3h after inoculation, while only 2 transcripts were down-regulated. At 6h, 658 up-regulated transcripts were noted, as compared to 188 down-regulated genes. By 24h after bacterial exposure, 1350 transcripts showed increased expression while 1632 exhibited reduced expression.

  • Research Products

    (10 results)

All 2010 2009 2008 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Remarks (1 results)

  • [Journal Article] Expression of IL-17 and its role in bone destruction in human middle ear cholesteatoma.2010

    • Author(s)
      Furukawa M, Kusunoki T, Onoda J, Ikeda K., Haruyama T
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec. 72(6)

      Pages: 325-331

    • Peer Reviewed
  • [Journal Article] A randomized prospective study of oral levofloxacin vs intravenous flomoxef prophylaxis in postoperative infection after endoscopic sinus surgery.2010

    • Author(s)
      Inosita A, Yokoi H, Matsumoto F, Yao T, Kawano K Furukawa M, Ikeda K
    • Journal Title

      Am J Otolaryngol. 31(5)

      Pages: 360-363

    • Peer Reviewed
  • [Journal Article] Overexpression of GLUT-1 in the invasion front is associated with depth of oral squamous cell carcinoma and prognosis.2010

    • Author(s)
      Ohba S, Fujii H, Ito S, Fujimaki, M, Matsumoto F, Furukawa M, Yokoyama J, Kusunoki T, Ikeda K, Hino O
    • Journal Title

      J Oral Pathol Med. 39(1)

      Pages: 74-78

    • Peer Reviewed
  • [Journal Article] Development of distortion product otoacoustic emissions in C57BL/6J mice.2009

    • Author(s)
      Narui Y, Minekawa A, Iizuka T, Furukawa M, Kusunoki T, Koike T, Ikeda K
    • Journal Title

      Int J Audiol. 48(8)

      Pages: 576-581

    • Peer Reviewed
  • [Journal Article] Prevention of ultrasonic coagulator-mediated mucoperiosteal flap injury and defects by using a clip manipulation in the resection of the posterior nasal nerve.2009

    • Author(s)
      Ikeda K, Yokoi H, Saito T, kawano K, Yao T, Furukawa M, Kusunoki T
    • Journal Title

      Rhinology. 47(1)

      Pages: 45-47

    • Peer Reviewed
  • [Journal Article] Eotaxin-1, -2, and-3 immunoreactivity and protein concentration in the nasal polyps of eosinophilic chronic rhinosinusitis patients.2009

    • Author(s)
      Yao T, Kojima Y, Koyanagi A, Yokoi H, Saito T, Kawano K, Furukawa M, Kusunoki T, Ikeda K
    • Journal Title

      Laryngoscope. 119(6)

      Pages: 1053-1059

    • Peer Reviewed
  • [Journal Article] Laryngeal stenosis in epidermolysis bullosa dystrophica.2009

    • Author(s)
      Haruyama T, Furukawa M, Matsumoto F, Kawano K, Ikeda K
    • Journal Title

      Auris Nasus Larynx. 36(1)

      Pages: 106-109

    • Peer Reviewed
  • [Journal Article] Clinical effectiveness of ototopical application of mupirocin ointment in methicillin-resistant Staphylococcus aureus otorrhea.2008

    • Author(s)
      Furukawa M, Minekawa A, Haruyama T, Narui Y, Sugita G, Sugita R, Kusunoki T, Ikeda K
    • Journal Title

      Otol Neurotol. 29(5)

      Pages: 676-678

    • Peer Reviewed
  • [Journal Article] Postnasal development of the organ of Corti in dominant-negative Gjb2 transgenic mice.2008

    • Author(s)
      Inoshita A, Iizuka T, Okamura HO, Minekawa A, Kojima K, Furukawa M, Kusunoki T, Ikeda K
    • Journal Title

      Neuroscience. 156(4)

      Pages: 1039-1047

    • Peer Reviewed
  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2016-04-21  

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