2010 Fiscal Year Final Research Report
Role of lipoxin as an inhibitory mediator in upper airway inflammation
| Project/Area Number |
20591999
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
SHIMIZU Takeshi Shiga University of Medical Science, 医学部, 教授 (00206202)
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| Co-Investigator(Kenkyū-buntansha) |
SENO Satoshi 滋賀医科大学, 医学部, 助教 (90378464)
SHIBAYAMA Masayuki 滋賀医科大学, 医学部, 助教 (20402711)
HOSHI Eriko 滋賀医科大学, 医学部, 助教 (20467385)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 鼻科学 |
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| Research Abstract |
To elucidate the inhibitory role of lipoxin A4 in upper airway inflammation, we examined the concentration of lipoxin A4 in nasal secretion, and tissue localization of ALX/FPRL-1 receptor in nasal mucosa. In vitro effects of lipoxin A4 on IL-8 secretion from cultured human airway epithelial cells were also examined.
Significant concentrations of lipoxin A4 were found in nasal secretion from patients with allergic rhinitis and chronic rhinosinusitis. ALX/FPRL-1 receptor was detected in epithelial cells, submucosal gland cells and infiltrating cells in nasal mucosa. Increased expression of ALX/FPRL-1 receptor mRNA was found in nasal polyp, compared with nasal mucosa of inferior turbinate. Lipoxin A4 significantly inhibited TNF-alpha-induced IL-8 secretion from cultured human normal bronchial epithelial cells.
These results indicate that lipoxin A4 may be an important inhibitory mediator in the pathogenesis of upper airway inflammation.
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