2010 Fiscal Year Final Research Report
Clinical usefulness and application of Taxol-resisitance molecules
| Project/Area Number |
20592014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
MASUYAMA Keisuke University of Yamanashi, 大学院・医学工学総合研究部, 教授 (30181663)
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| Co-Investigator(Kenkyū-buntansha) |
CHIKAMATSU Ichiro 山梨大学, 医学部附属病院, 講師 (30301378)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUOKA Tomokazu 山梨大学, 大学院・医学工学総合研究部, 助教 (30313810)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 抗癌剤耐性分子 / 癌幹細胞 / 制御性T細胞 |
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| Research Abstract |
We found that head and neck cancer stem cells appeared to be resistant to the treatment of anti-cancer drugs. We did not find any differences of TRAG-3 mRNA expressions between CD44+ and CD44- cells of head and neck cancer cell lines. In addition, CD44+ cells significantly suppressed T cell proliferation. As for cytokine production, IFN・was reduced, however, IL-10 was increased when co-cultured with CD44+ cells. Thus, immunosuppressive mechanisims other than TRAG-3 expression may have a role for anti-cancer drug resistance.
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