2010 Fiscal Year Final Research Report
The role of Thymidylate Synthase (TS) and Dihydropyrimidine Dehydrogenase (DPD)expression in 5-FU based chemoradiation for head and neck cancer
| Project/Area Number |
20592021
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKASHIMA Torahiko Kyushu University, 大学病院, 講師 (00284505)
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| Co-Investigator(Kenkyū-buntansha) |
YASUMATSU Ryuji 九州大学, 医学研究院, 研究員 (00444787)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 頭頸部癌 / 放射線化学療法 / 核酸代謝酵素 |
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| Research Abstract |
Thymidylate Synthase (TS) and Dihydropyrimidine Dehydrogenase (DPD) are key enzymes for 5-FU metabolism. The relationship between the expression of TS/DPD and 5-FU sensitivity in head and neck squamous carcinoma (HNSCC) cells was analyzed in vitro.
Increasing the expression of TS or DPD decreased the cytotoxicity of 5-FU against HNSCC cells.
Clinico-pathological analysis was also performed utilizing specimens from oral cancer and maxillary sinus cancer. There was a correlation between high TS expression and poor prognosis of the patients. Assessment of TS/DPD activity may be useful in predicting the effect and prognosis of HNSCC patients who are receiving 5-FU based chemo(radio)therapy.
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