Physiological evidence of supracricoid laryngectomy with CHEP

2011 Fiscal Year Final Research Report

• Project/Area Number: 20592028
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kitasato University
• Principal Investigator: NAKAYAMA Meijin 北里大学, 医学部, 講師 (20207955)
• Project Period (FY): 2008 – 2011
• Keywords: Cricoarytenoid Unit / MDCT / 高速度撮影 / 喉頭機能温存 / 喉頭癌

Research Abstract

Three projects were conducted and the results reported.
1) Electromyography of cricoarytenoid unit : Mobility of the arytenoid was attributed to interaction between the interarytenoid muscle and posterior cricoarytenoid muscle. Reciprocal interaction between the interarytenoid muscle and posterior cricoarytenoid muscle alone is also capable of maintaining post-operative laryngeal functions after supracricoid laryngectomy with cricohyoidoepiglottopexy.
2) MDCT analysis of CAU : Anterior shifting of the unilateral arytenoid plays an important role in compensating for the inability to achieve neoglottic closure. These two results demonstrate that the unilateral arytenoid alone is capable of achieving sufficient neoglottic narrowing to compensate for the resected arytenoid. Three-dimensional analysis was useful to evaluate the physiological status of the neoglottis after supracricoid laryngectomy with cricohyoidoepiglottopexy.
3) High-speed digital imaging laryngoscopy of neoglottis : High-speed digital imaging analysis is effective in locating the sites responsible for voice production in patients who have undergone supracricoid laryngectomy with cricohyoidoepiglottopexy. This is the first study to clearly identify the neoglottal sound source in such patients, using a high-speed digital imaging system.

Research Products

• [Journal Article] Functional organ preservation for laryngeal cancer : Past, Present, and Future (2012)
  • Author(s): Nakayama, M., Laccourreye, O., Helsingr, C., Makito, O., Hayakawa, K
  • Journal Title: Jpn J Clin Oncol Volume: 42(3) Pages: 155-160
  • Peer Reviewed
• [Journal Article] Three-dimensional computed tomography analysis of neoglottis after supracricoid laryngectomy with CHEP (2012)
  • Author(s): Seino, Y., Nakayama, M., Okamoto, M., Hayashi, S
  • Journal Title: J Laryngol Otol
  • Peer Reviewed
• [Journal Article] Clinical significance of intraoperative surgical margin study in supracricoid laryngectomy (2011)
  • Author(s): Nakayama, M., Okamoto, M., Iwabuchi, K., Mikami, T., Seino, Y
  • Journal Title: Auris Nasus Larynx Volume: 38 Pages: 261-265
  • Peer Reviewed
• [Journal Article] Delayed wound infection after supracricoid partial laryngectomy following failure of high dose radiation (2011)
  • Author(s): Nakayama, M., Okamoto, M., Seino, Y., Miyamoto, S., Matsuki, T., Ogawa, A
  • Journal Title: Eur Arch Otorhinolaryngol Volume: 268 Pages: 273-279
• [Journal Article] High speed digital imaging laryngoscopy of the neoglottis following supracricoid laryngectomy with cricohyoidoepiglottopexy (2010)
  • Author(s): Hayashi, S., Hirose, H., Tayama, N., Imagawa, H., Nakayama, M., Seino, Y., Okamoto, M., Kimura, M., Nito, T
  • Journal Title: J Laryngol Otol Volume: 124 Pages: 1234-1238
  • Peer Reviewed
• [Journal Article] Inverted epiglottis : A postoperative complication of supracricoid laryngectomy with cricohyoidoepiglottopexy (2010)
  • Author(s): Nakayama, M., Okamoto, M., Seino, Y., Miyamoto, S., Hayashi, S., Masaki, T., Yokobori, S., Takeda M
  • Journal Title: Auris Nasus Larynx Volume: 37 Pages: 609-614
  • Peer Reviewed
• [Journal Article] Electromyography of the cricoarytenoid unit during supracricoid laryngectomy with a cricohyoidoepiglottopexy procedure (2007)
  • Author(s): Nakayama, M., Hirose, H., Miyamoto, S., Yokobori, S., Takeda, M., Seino, Y., Okamoto, M
  • Journal Title: J Laryngol Otol Volume: 121 Pages: 87-91
  • Peer Reviewed
• [Presentation] Autologous fat augmentation for insufficient neoglottal closure after SCL-CHEP : A preliminary report (2012)
  • Author(s): Nakayama, M., Watanabe, A., Tamura, e., Okamoto T., Y, Seino., Shunsuke M., Okamoto M
  • Organizer: 14th Japan-Korea ORL-HNS meeting
  • Place of Presentation: Kyoto Hotel Okura
  • Year and Date: 20120413-14
• [Presentation] Supracricoid laryngectomy : Is there still a role for salvage SCPL-CHEP (2012)
  • Author(s): Nakayama, M
  • Organizer: Combined workshop for Head and Neck Surgery
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20120300
• [Presentation] Is there still a role for salvage SCPL-CHEP (2011)
  • Author(s): Nakayama, M., Seino Y., Okamoto M., Shunsuke M., Okamoto T
  • Organizer: AAO-HNS Annual meeting
  • Place of Presentation: San Francisco Convention Center, USA
  • Year and Date: 20110910-13
• [Presentation] Salvage SCPL-CHEP (2011)
  • Author(s): Nakayama, M
  • Organizer: Annual meeting of Taiwan Head and Neck Cancer Association
  • Place of Presentation: Kaohsiung
  • Year and Date: 20110700
• [Presentation] Clinical significance of positive Delphian node in supracricoid laryngectomy with cricohyoidoepiglottopexy (2011)
  • Author(s): Nakayama, M., Seino Y., Okamoto M., Shunsuke M., Okamoto T
  • Organizer: The 12th Asia-Oceania Otolaryngology Head and Neck Congress
  • Place of Presentation: Aotea Centre, Auckland, New Zealand
  • Year and Date: 20110301-04
• [Presentation] Flaccid neoglottis following supracricoid laryngectomy : laryngoscopic revision assisted by navigation system (2010)
  • Author(s): Nakayama, M., Matsuki, T., Okamoto, M., Seino Y
  • Organizer: The 4th World Voice Congress 2010
  • Place of Presentation: Coex convention center, Seoul
  • Year and Date: 20100906-09
• [Presentation] Delayed wound infection after supracricoid laryngectomy following failure of high dose radiation (2010)
  • Author(s): Nakayama, M., Okamoto, M., Seino Y., Shunsuke M., Hayashi S
  • Organizer: The 4th World Congress of International Federation of Head and Neck Oncologic Societies, IFHNOS 2010
  • Place of Presentation: Lotte Hotel Seoul
  • Year and Date: 20100615-19
• [Book] Atlas of Head and Neck Surgery (2011)
  • Author(s): Nakayama, M
  • Publisher: Elsevier Saunders
• [Book] EBM耳鼻咽喉科・頭頸部外科の治療-喉頭亜全摘出術のEBMとは? (2010)
  • Author(s): 中山明仁、岡本牧人
  • Publisher: 中外医学社