2010 Fiscal Year Final Research Report
Research for genes associated with glaucoma
| Project/Area Number |
20592033
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KABURAKI Toshikatsu The University of Tokyo, 医学部付属病院, 講師 (00280941)
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| Co-Investigator(Kenkyū-buntansha) |
ARAIE Makoto 東京大学, 医学部附属病院, 教授 (00092122)
TOKUNAGA Katsushi 東京大学, 大学院・医学系研究科, 教授 (40163977)
MABUCHI Akihiko 東京大学, 大学院・医学系研究科, 准教授 (80312312)
NUMAGA Jiro 東京都高齢者研究・福祉振興財団東京都, 老人総合研究所, 研究員 (30189352)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 眼遺伝学 / 緑内障 / 遺伝子 / ゲノムワイド / 関連解析 |
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| Research Abstract |
To identify the susceptible genes for normal tension glaucoma (NTG), we collected blood samples from more than 600 Japanese patients with NTG and extracted DNA. We performed genome-wide association study with DNA microarray using 280 samples from NTG patients and 560 healthy controls as the 1st screening. Moreover, the 2nd screening and replication study were performed using the indipendent case and control sets. As the results, we found a gene locus that might be closely associated with the susceptibility of NTG.
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Research Products
(37 results)
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[Journal Article] Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan.2009
Author(s)
Asukata Y, Ota M, Meguro A, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Inoko H, Ohno S, Mizuki N.
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Journal Title
Mol Vis. 15
Pages: 2673-82
Peer Reviewed
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[Remarks] ホームページ等
