2010 Fiscal Year Final Research Report
Pathological clarification of glaucoma by structural and functional evaluation of retinal nerve fiber layer defects
| Project/Area Number |
20592034
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kanazawa University |
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Principal Investigator |
OHKUBO Shinji Kanazawa University, 附属病院, 助教 (90362003)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIYAMA Kazuhisa 金沢大学, 医学系, 教授 (80179168)
HIGASHIDE Tomomi 金沢大学, 附属病院, 講師 (20291370)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 極早期緑内障 / 網膜神経線維層欠損 / 光干渉断層計 / 視野 |
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| Research Abstract |
We evaluated structure and function of glaucoma subjects with localized retinal nerve fiber layer defects not accompanied by a perimetric defect according to standard automated perimetry (pre-perimetric glaucoma). Fundus-oriented small-target perimetry was a useful method to detect visual field abnormalities in pre-perimetric glaucoma. The relationship of structure and function of the retinal nerve fiber layer defect was clarified by using fundus-oriented perimetry and optical coherence tomography. Deep defect parts and shallow defect parts are present in a retinal nerve fiber layer defect and it became clear that there was visual field sensitivity depression in the deep defect part of the retinal nerve fiber layer defect.
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[Journal Article] Peripapillary retinal nerve fiber layer thickness determined by spectral-domain optical coherence tomography in ophthalmologically normal eyes.2010
Author(s)
Hirasawa H, Tomidokoro A, Araie M, Konno S, Saito H, Iwase A, Shirakashi M, Abe H, Ohkubo S, Sugiyama K, Ootani T, Kishi S, Matsushita K, Maeda N, Hangai M, Yoshimura N.
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Journal Title
Arch Ophthalmol 128
Pages: 1420-1426
Peer Reviewed
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