2010 Fiscal Year Final Research Report
In vivo quantitative evaluation of optic nerve damage in animal models related to glaucoma by a ultrahigh-resolution optical coherence tomography
| Project/Area Number |
20592035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kanazawa University |
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Principal Investigator |
HIGASHIDE Tomomi Kanazawa University, 附属病院, 講師 (20291370)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 光干渉断層計 / ラット / 緑内障モデル |
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| Research Abstract |
We examined the changes of the thickness of retinal nerve fiber layer in rat eyes after optic nerve crush by our optical coherence tomography which was optimized to rat eyes. The thickness value measured by the optical coherence tomography showed good repeatability and reproducibility, and was well correlated with that measured by histology. After introduction of multiple scan averaging and an auto-segmentation program, we disclosed that the thickness of the retinal nerve fiber layer decreases following the decrease in the thickness of the inner retinal layer in rat eyes after an intravitreal injection of endothelin-1.
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