Role of neural guidance factor on cornal epithelial wound healing.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20592045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Yamaguchi University
• Principal Investigator: KO Jiae Yamaguchi University, 大学院・医学系研究科, 講師 (70314797)
• Co-Investigator(Kenkyū-buntansha): YANAI Ryoji 山口大学, 大学院・医学系研究科, 講師 (10346554)
• Project Period (FY): 2008 – 2010
• Keywords: 眼細胞生物学

Research Abstract

Semaphorin 3A released from corneal fibroblasts may play an important role in the regulation of intercellular communication between corneal epithelial cells as well as in maintenance of corneal structure, function and wound healing.

Research Products

• [Journal Article] Down-Regulation of Matrix Metalloproteinase-2 in Corneal Fibroblasts by Interleukin-1 Receptor Antagonist Release from Corneal Epithelial (2011)
  • Author(s): Ko J.-A., Yanai R., Chikama TI., Nishida T.
  • Journal Title: Cells.Invest.Ophthalmol.Vis.Sci. in press
  • Peer Reviewed
• [Journal Article] Expression of semaphoring 3A and its receptors during mouse corneal development. (2010)
  • Author(s): Ko J.-A., Mizuno Y., Yanai R., Chikama TI., Sonoda KH.
  • Journal Title: Biochem.Biophysic.Res.Commun. 403 Pages: 305-309
  • Peer Reviewed
• [Journal Article] Effects of semaphoring 3A overexpression in corneal fibroblasts on the expression of adherens-junction proteins in corneal epithelial cells. (2010)
  • Author(s): Ko J.-A., Akamatsu Y., Yanai R., Nishida T.
  • Journal Title: Biochem.Biophysic.Res.Commun. 396 Pages: 781-786
  • Peer Reviewed
• [Journal Article] Expression of semaphoring 3A in the rat corneal epithelium during wound healing. (2010)
  • Author(s): Morishige N., Ko J.-A., Morita Y. Nishida T.
  • Journal Title: Biochem.Biophysic.Res.Commun. 395 Pages: 451-457
  • Peer Reviewed
• [Journal Article] IGF-1 released by corneal epithelial cells induces up-regulation of N-cadherin in corneal fibroblasts. (2009)
  • Author(s): Ko J.-A., Yanai R., Nishida T.
  • Journal Title: J.Cell Physiol. 221 Pages: 254-261
  • Peer Reviewed
• [Presentation] Neural cells promotes the stratification of corneal epithelial cells by coculture system. (2010)
  • Author(s): Ko J.-A., Chikama TI., Sonoda KH.
  • Organizer: 50^<th> The American Society for Cell Biology
  • Place of Presentation: Philadelphia.
  • Year and Date: 2010-12-13
• [Presentation] IL-1RA released by corneal epithelial cells induces down-regulation of MMP-2 in cocultured corneal fibroblasts. (2009)
  • Author(s): Ko J.-A., Yanai R., Nishida T.
  • Organizer: 49^<th> The American Society for Cell Biology
  • Place of Presentation: San Diego.
  • Year and Date: 2009-12-06
• [Presentation] Semaphorin 3A強発現実質細胞による角膜上皮細胞でのAdherent Junction蛋白質の発現 (2009)
  • Author(s): 高知愛、柳井亮二、森重直行、西田輝夫
  • Organizer: 第113回日本眼科学会総会
  • Year and Date: 2009-04-16
• [Presentation] Up-Regulation of Semaphorin 3A in Human Corneal Fibroblasts by Epidermal Growth Factor Released from Cocultured Human Corneal Epithelial Cells. (2008)
  • Author(s): Ko J.-A., Morishige N., Nishida T
  • Organizer: 48^<th> The American Society for Cell Biology
  • Place of Presentation: San Francisco.
  • Year and Date: 2008-12-16
• [Presentation] 共培養による角膜実質細胞でのConnexin43, N-cadherin発現に対する角膜上皮細胞の作用 (2008)
  • Author(s): 高知愛、柳井亮二、西田輝夫
  • Organizer: 第55回マトリックス研究会大会
  • Year and Date: 2008-05-30
• [Remarks] ホームページ等
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~eye/