2010 Fiscal Year Final Research Report
Effect of enzymatic vitreolysis on the remodeling of the retinal vasculature
| Project/Area Number |
20592048
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Saga University |
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Principal Investigator |
AKIRA Hirata Saga University, 医学部, 准教授 (60295144)
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| Project Period (FY) |
2008 – 2010
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| Keywords | プラスミン / 後部硝子体剥離 / 網膜 |
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| Research Abstract |
A model of branch retinal vein occlusion was made on Brown Norway rat. After laser photocoagulation (PC), the retinas were observed. In earlyphase (1-3 days), massive exudative retinal detachment was observed. On day 7, the retinal detachment was absorbed completely. Histologically, the PC treated vessels contained numerous aggregated RBCs in early phase. Some vessels showed endothelial gaps. Intravitreal injection of plasmin in rat eyes showed posterior vitreous detachment in 25% (0.01U) to 50% (0.05-0.1U). Pretreatment of plasmin reduced the severity of retinal detachment after PC. Intravitreal injection of bevacizumab in rat eyes caused decreasing of the number of fenestrae in choriocapillaris transiently until 7days after injection.
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