Genome-wide association study of lattice degeneration of the retina using 23,465 microsatellite markers

2010 Fiscal Year Final Research Report

• Project/Area Number: 20592052
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Yokohama City University
• Principal Investigator: ITO Norihiko Yokohama City University, 医学部, 助教 (80264654)
• Co-Investigator(Kenkyū-buntansha): MIZUKI Nobuhisa 横浜市立大学, 医学研究科, 教授 (90336579)
• Co-Investigator(Renkei-kenkyūsha): OHNO Shigeaki 北海道大学, 医学研究科, 特任教授 (50002382) ; INOKO Hidetoshi 東海大学, 医学部, 教授 (10101932)
• Project Period (FY): 2008 – 2010
• Keywords: ゲノムワイド相関解析 / マイクロサテライト / SNP / 網膜格子状変性

Research Abstract

To identify susceptibility genes for lattice degeneration of the retina, we performed a genome-wide association study using a comprehensive set 23,465 microsatellite markers in 574 Japanese cases and 608 controls, and identified the disease-associated gene for the disease.

Research Products

• [Journal Article] Investigation of Association between TLR9 Gene Polymorphisms and VKH in Japanese Patients. (2011)
  • Author(s): Ito R, Ota M, Meguro A, Katsuyama Y, Uemoto R, Nomura E, Nishide T, Kitaichi N, Horie Y, Namba K, Ohno S, Inoko H, Mizuki N.
  • Journal Title: Ocul Immunol Inflamm 19(3) Pages: 202-205
• [Journal Article] Investigation of the association between SLC1A3 gene polymorphisms and normal tension glaucoma. (2011)
  • Author(s): Yasumura R, Meguro A, Ota M, Nomura E, Uemoto R, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.
  • Journal Title: Mol Vis 17 Pages: 792-796
• [Journal Article] Toll-like receptor 2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese. (2011)
  • Author(s): Sato M, Kawagoe T, Meguro A, Ota M, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Ohno S, Inoko H, Mizuki N.
  • Journal Title: Mol Vis 17 Pages: 731-736
• [Journal Article] Association analysis of Toll-like receptor 7 gene polymorphisms and Behcet's disease in Japanese. (2011)
  • Author(s): Sada T, Ota M, Katsuyama Y, Meguro A, Nomura E, Uemoto R, Nishide T, Okada E, Ohno S, Inoko H, Mizuki N.
  • Journal Title: Hum Immunol 72(3) Pages: 269-272
• [Journal Article] Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci. (2010)
  • Author(s): Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T, Ito N, Kera J, Okada E, Yatsu K, Song YW, Lee EB, Kitaichi N, Namba K, Horie Y, Takeno M, Sugita S, Mochizuki M, Bahram S, Ishigatsubo Y, Inoko H.
  • Journal Title: Nat Genet 42(8) Pages: 703-706
• [Journal Article] Genetics of Behcet disease inside and outside the MHC. (2010)
  • Author(s): Meguro A, Inoko H, Ota M, Katsuyama Y, Oka A, Okada E, Yamakawa R, Yuasa T, Fujioka T, Ohno S, Bahram S, Mizuki N.
  • Journal Title: Ann Rheum Dis 69(4) Pages: 747-754
• [Journal Article] Genome-wide association study of normal tension glaucoma : common variants in SRBD1 and ELOVL5 contribute to disease susceptibility. (2010)
  • Author(s): Meguro A, Inoko H, Ota M, Mizuki N, Bahram S, Writing Committee for the Normal Tension Glaucoma Genetic Study Group of Japan Glaucoma Society.
  • Journal Title: Ophthalmology 117(7) Pages: 1331-1338
• [Journal Article] Genotyping HLA-DRB1 and HLA-DQB1 alleles in Japanese patients with normal tension glaucoma. (2010)
  • Author(s): Suzuki M, Meguro A, Ota M, Nomura E, Kato T, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.
  • Journal Title: Mol Vis 16 Pages: 1874-1879
• [Journal Article] TRIM39 and RNF39 are associated with Behcet's disease independently of HLA-B*51 and -A*26. (2010)
  • Author(s): Kurata R, Nakaoka H, Tajima A, Hosomichi K, Shiina T, Meguro A, Mizuki N, Ohono S, Inoue I, Inoko H.
  • Journal Title: Biochem Biophys Res Commun 401(4) Pages: 533-537
• [Journal Article] Eicosapentaenoic acid suppresses ocular inflammation in endotoxin-induced uveitis. (2010)
  • Author(s): Suzuki M, Noda K, Kubota S, Hirasawa M, Ozawa Y, Tsubota K, Mizuki N, Ishida S.
  • Journal Title: Mol Vis. 16 Pages: 1382-1388
• [Journal Article] Natural killer cells control a T-helper 1 response in patients with Behcet's disease. (2010)
  • Author(s): Yamaguchi Y, Takahashi H, Satoh T, Okazaki Y, Mizuki N, Takahashi K, Ikezawa Z, Kuwana M.
  • Journal Title: Arthritis Res Ther 12(3) Pages: R80
• [Journal Article] Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma. (2010)
  • Author(s): Murakami K, Meguro A, Ota M, Shiota T, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.
  • Journal Title: Mol Vis 16 Pages: 462-466
• [Journal Article] Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. (2009)
  • Author(s): Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki N, Alexander JS, Peterson ML, Brekken RA, Hirashima M, Capoor S, Usui T, Ambati BK, Ambati J.
  • Journal Title: Nat Med 15(9) Pages: 1023-1030
• [Journal Article] Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population. (2009)
  • Author(s): Nakamura K, Ota M, Meguro A, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.
  • Journal Title: Clin Ophthalmol 3 Pages: 307-312
• [Journal Article] Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis. (2009)
  • Author(s): Kamio M, Meguro A, Ota M, Nomura N, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.
  • Journal Title: Clin Ophthalmol 3 Pages: 183-188
• [Journal Article] Association of TLR4 polymorphisms with Behcet's disease in a Korean population. (2009)
  • Author(s): Horie Y, Meguro A, Ota M, Kitaichi N, Katsuyama Y, Takemoto Y, Namba K, Yoshida K, Song YW, Park KS, Lee EB, Inoko H, Mizuki N, Ohno S.
  • Journal Title: Rheumatology 48(6) Pages: 638-642
• [Journal Article] Investigation of the association between Toll-like receptor 2 gene polymorphisms and Behcet's disease in Japanese patients. (2009)
  • Author(s): Tomiyama R, Meguro A, Ota M, Katsuyama Y, Nishide T, Uemoto R, Iijima Y, Ohno S, Inoko H, Mizuki N.
  • Journal Title: Hum Immunol 70(1) Pages: 41-44
• [Journal Article] Association of toll-like receptor 2 gene polymorphisms with normal tension glaucoma. (2009)
  • Author(s): Nakamura J, Meguro A, Ota M, Nomura E, Nishide T, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.
  • Journal Title: Mol Vis 15 Pages: 2905-2910
• [Journal Article] Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan. (2009)
  • Author(s): Asukata Y, Ota M, Meguro A, Katsuyama Y, Ishihara M, Namba K, Kitaichi N, Morimoto S, Kaburaki T, Ando Y, Takenaka S, Inoko H, Ohno S, Mizuki N.
  • Journal Title: Mol Vis 15 Pages: 2673-2682
• [Journal Article] New susceptibility locus for high myopia is linked to the uromodulin-like 1 (UMODL1) gene region on chromosome 21q22.3. (2009)
  • Author(s): Nishizaki R, Ota M, Inoko H, Meguro A, Shiota T, Okada E, Mok J, Oka A, Ohno S, Mizuki N.
  • Journal Title: Eye 23(1) Pages: 222-229
• [Journal Article] Association of the toll-like receptor 4 gene polymorphisms with Behcet's disease. (2008)
  • Author(s): Meguro A, Ota M, Katsuyama Y, Oka A, Ohno S, Inoko H, Mizuki N.
  • Journal Title: Ann Rheum Dis 67(5) Pages: 725-727
• [Journal Article] Association of toll-like receptor 4 gene polymorphisms with normal tension glaucoma. (2008)
  • Author(s): Shibuya E, Meguro A, Ota M, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Ohno S, Inoko H, Mizuki N.
  • Journal Title: Invest Ophthalmol Vis Sci 49(10) Pages: 4453-4457
• [Journal Article] Four-digit allele genotyping of HLA-A and HLA-B genes in Japanese patients with Behcet's disease. (2008)
  • Author(s): Kamiishi T, Itoh Y, Meguro A, Nishida T, Sasaki S, Nanba K, Ohno S, Inoko H, Mizuki N.
  • Journal Title: Nippon Ganka Gakkai Zasshi 112(5) Pages: 451-458
• [Journal Article] A mouse model of allogeneic corneal endothelial cell transplantation. (2008)
  • Author(s): Hayashi T, Yamagami S, Tanaka K, Yokoo S, Usui T, Amano S, Mizuki N.
  • Journal Title: Cornea 27(6) Pages: 699-705
• [Journal Article] Bilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease. (2008)
  • Author(s): Hayashi T, Ishioka M, Ito N, Kato Y, Nakagawa H, Hatano H, Mizuki N.
  • Journal Title: Clin Ophthalmol 2(2) Pages: 457-459
• [Journal Article] Guidelines for the diagnosis of ocular sarcoidosis. (2008)
  • Author(s): Asukata Y, Ishihara M, Hasumi Y, Nakamura S, Hayashi K, Ohno S, Mizuki N.
  • Journal Title: Ocul Immunol Inflamm 16(3) Pages: 77-81
• [Journal Article] Rac1 mediates phorbol 12-myristate 13-acetate-induced migration of glioblastoma cells via paxillin. (2008)
  • Author(s): Nomura N, Nomura M, Mizuki N, Hamada J.
  • Journal Title: Oncol Rep 20(4) Pages: 705-711
• [Journal Article] Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behcet's disease. (2008)
  • Author(s): Kirino Y, Takeno M, Watanabe R, Murakami S, Kobayashi M, Ideguchi H, Ihata A, Ohno S, Ueda A, Mizuki N, Ishigatsubo Y.
  • Journal Title: Arthritis Res Ther 10(1) Pages: R16
• [Presentation] Genome-wide association study of lattice degeneration of the retina using 23,465 microsatellite markers. (2011)
  • Author(s): Meguro A, Ideta H, Ota M, Ideta R, Inoko H, Mizuki N.
  • Organizer: Asia Pacific Academy of Ophthalmology Congress 2011
  • Place of Presentation: Sydney, Australia
  • Year and Date: 20110300