2010 Fiscal Year Final Research Report
Microarray analysis of proliferative vitreoretinopathy to identify molecular targets for new diagnosis and therapy
| Project/Area Number |
20592066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Fukuoka University |
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Principal Investigator |
YOSHIDA Shigeo Fukuoka University, 大学病院, 講師 (50363370)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIBASHI Tatsuro 九州大学, 医学研究院, 教授 (30150428)
KONO Toshihiro 福岡大学, 医学部, 教授 (40161880)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ゲノム医科学 / 増殖硝子体網膜症 / 遺伝子発現 |
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| Research Abstract |
We performed global gene expression analysis using epiretinal membranes (ERMs) from patients with proliferative vitreoretinopathy (PVR) and mouse model of ischemic retinopathy. Genes preferentially expressed in ERMs were subdivided by the functional sets of genes such as oxidative phosphorylation, cell adhesion, cell communication, cytokine-receptor association. Periostin was expressed in ERMs which located in smooth muscle actin-positive cells. In mouse model of ischemic retinopathy, MIP1β was upregulated in ischemic inner retina and was associated with physiological retinal revascularization.
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