2010 Fiscal Year Final Research Report
Pharmacological effect of various Prostaglandin analogues on ciliary artery smooth muscle cells
| Project/Area Number |
20592070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Akita University |
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Principal Investigator |
YOSHITOMI Takeshi Akita University, 大学院・医学系研究科, 教授 (60191623)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Noriko 秋田大学, 大学院・医学系研究科, 助教 (60431623)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 緑内障 / 眼循環 / 血管収縮 / 正常眼圧緑内障 / 眼血流 / 血管平滑筋 / 細胞内カルシウム動態 / プロスタグランディン |
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| Research Abstract |
Prostaglandin (PG) analogues lower IOP and have been widely used as ocular hypotensive drugs for the treatment of glaucoma. We investigated the effect of this drugs on ocular circulation. Topical PG also increases ocular blood flow measured by the laser speckle method. PG analogues also concentration-dependently relaxed mouse ciliary artery in vitro. This relaxation was also observed in prostanoid FP receptor-deficient mouse ciliary arteries. Thus, we conclude that the PG analogues relaxes ciliary arteries not dependent on prostanoid FP receptors
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