2010 Fiscal Year Final Research Report
Analysis for mechanisms of immune suppression by human corneal endothelial cells
| Project/Area Number |
20592073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SUGITA Sunao Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 講師 (10299456)
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| Co-Investigator(Kenkyū-buntansha) |
MOCHIZUKI Manabu 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (10010464)
SUGAMOTO Yoshiharu 東京医科歯科大学, 医学部附属病院, 講師 (20334419)
KAMOI Koju 東京医科歯科大学, 医学部附属病院, 助教 (40451942)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 角膜内皮細胞 / T細胞 / 免疫寛容 |
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| Research Abstract |
Corneal endothelial cells have immunosuppressive activities. We report here that human corneal endothelial cell lines significantly suppressed activation of CD4^+ T cells, CD8^+ T cells, pan-T cells in vitro. Moreover, cultured corneal endothelial cell lines converted CD8^+ T cells into Treg cells that have immunosuppressive capacity. The CE-induced Treg cells greatly expressed CD25high and Foxp3. Therefore, we demonstrated that human corneal endothelial cells indicate suppression of bystander T cell activation and induction of regulatory T cells in vitro.
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Research Products
(7 results)
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[Journal Article] Human corneal endothelial cells expressing programmed death-ligand 1 (PD-L1) suppress PD-1^+ T helper 1 cells by a contact-dependent mechanism.2009
Author(s)
Sugita S, Usui Y, Horie S, Futagami Y, Yamada Y, Ma J, Kezuka T, Hamada H, Usui T, Mochizuki M, Yamagami S.
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Journal Title
Invest.Ophthalmol.Vis.Sci. 50
Pages: 263-272
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[Remarks] ホームページ等
