2010 Fiscal Year Final Research Report
Generation of nitric oxide synthase transgenic mice and analysis of their visual function
| Project/Area Number |
20592074
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagoya University |
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Principal Investigator |
KOMEIMA Keiichi Nagoya University, 大学院・医学系研究科, 助教 (40362256)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Mineo 名古屋大学, 大学院・医学系研究科, 准教授 (80303642)
TERASAKI Hiroko 名古屋大学, 大学院・医学系研究科, 教授 (40207478)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 一酸化窒素(NO) / 誘導型一酸化窒素合成酵素(iNOS) / 網膜色素上皮細胞 / トランスジェニックマウス / 酸化・ニトロ化ストレス / VMD2プロモーター / 加齢黄斑変性 / 網膜色素変性症 |
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| Research Abstract |
We generated 5 lines of inducible nitric oxide synthase transgenic mice. Fundus examination revealed retinal drusen in 3 lines of transgenic mice. These results indicated that nitric oxide overexpressed in the outer layer of retinas caused oxidative stress and degenerative change in mouse retinas as is seen in the patients of age-related macular degeneration.
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[Journal Article] Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa.2009
Author(s)
Usui S, Komeima K, Lee SY, Jo YJ, Ueno S, Rogers BS, Wu Z, Shen J, Lu L, Oveson BC, Rabinovitch PS, Campochiaro PA.
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Journal Title
Mol Ther. 17
Pages: 778-786
Peer Reviewed
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