2010 Fiscal Year Final Research Report
The inhibition of subretinal fibrosis due to choroidal neovascularization
| Project/Area Number |
20592080
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyushu University |
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Principal Investigator |
SONODA Kohei Kyushu University, 大学院・医学系研究科, 教授 (10294943)
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| Co-Investigator(Kenkyū-buntansha) |
HATA Yasuaki 福岡歯科大学, 眼科, 教授 (90346776)
ISHIBASHI Tatsuro 九州大学, 大学院・医学研究院, 教授 (30150428)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 自然免疫 / 脈絡膜血管新生 / 網膜瘢痕 / 遺伝子治療 |
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| Research Abstract |
Activated macrophages formed subretinal fibrosis when they were placed in the subretinal space and induce myofibrotic changes in RPE cells. The major factors to form fibrosis were IL-6 and MCP-1. We confirmed the in vivo blocking of IL-6 and MCP-1 reduced subretinal fibrosis and might be beneficial to maintain visual acuity in CNV-related diseases.
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