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2010 Fiscal Year Final Research Report

Development of neuroprotective therapy using electrical retinal stimulation

Research Project

  • PDF
Project/Area Number 20592081
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionOita University

Principal Investigator

SHINODA Kei  Oita University, 医学部, 准教授 (60245561)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Soiti  帝京大学, 医学部, 講師 (00305054)
TSUNODA Kazushige  (独)国立病院機構, 視覚生理研究室, 室長 (30255525)
OZEKI Naoki  慶応義塾大学, 医学部, 助教 (80383826)
NAKATSUKA Kazuo  大分大学, 医学部, 教授 (20112378)
KIMOTO Kenichi  大分大学, 医学部, 講師 (50315339)
YAMADA Kisaburo  大分大学, 医学部, 助教 (50452909)
Project Period (FY) 2008 – 2010
Keywords網膜電気刺激 / 網膜電図 / 網膜内因性信号
Research Abstract

Optimal protocol of the neuroprotective therapy using electrical retinal stimulation was determined by means of intrinsic signal in the functional retinography and of electrically evoked response. Prospective clinical tests of the electrical retinal stimulation for several retinal and/or optic nerve diseases showed no significant adverse effect except mild corneal epithelial defects and not only subjective but also objective improvement in visual function in selected cases.

  • Research Products

    (41 results)

All 2011 2010 2009 2008

All Journal Article (9 results) Presentation (28 results) Book (4 results)

  • [Journal Article] High Correlation of Scotopic and Photopic ERG Components with Severity of Ocular Circulation Disturbances Following Central Retinal Artery Occlusion.2011

    • Author(s)
      Matsumoto CS, Shinoda K, Nakatsuka K
    • Journal Title

      Clin Ophthalmol 5

      Pages: 115-21

  • [Journal Article] Pattern-reversal visual evoked potential in patients with occult macular dystrophy.2010

    • Author(s)
      Hanazono G, Shinoda K, Tsunoda K, Miyake Y
    • Journal Title

      Clin Ophthalmol 4

      Pages: 1515-20

  • [Journal Article] Optical Coherence Tomographic Evaluation of Outer Retinal Architecture in Oguchi Disease.2009

    • Author(s)
      Yamada K, Motomura Y,Matsumoto CS, Shinoda K,, Nakatsuka K
    • Journal Title

      Jp J Ophthalmol 53(5)

      Pages: 449-51

  • [Journal Article] Mechanism of Patients' Visual Sensations during Pars Plana Vitrectomy under Retrobulbar Anesthesia.2009

    • Author(s)
      Sugisaka E, Shinoda K
    • Journal Title

      Ophthalmologica 224(2)

      Pages: 103-108

  • [Journal Article] The photopic negative response reflects the severity of circulation damage in central retinal arterial occlusion.2009

    • Author(s)
      松本惣一セルソ, 篠田啓
    • Journal Title

      Ophthalmologica 223(6)

      Pages: 362-369

  • [Journal Article] Transcutaneous electrical retinal stimulation therapy for age-related macular degeneration.2008

    • Author(s)
      篠田啓
    • Journal Title

      Open Ophthalmol 2

      Pages: 132-136

  • [Journal Article] Changes in Retinal Thickness is Correlated with Alterations of Electroretinogram in Eyes with Ce ntral Retinal Artery Occlusion.2008

    • Author(s)
      篠田啓, 松本惣一セルソ
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 246(7)

      Pages: 949-54

  • [Journal Article] Distribution of retinal responses evoked by transscleral electrical stimulation detected by intrinsic signal imaging in macaque monkeys.2008

    • Author(s)
      Inomata K, Tsunoda K, Shinoda K, Miyake Y
    • Journal Title

      Invest Ophthalmol Vis Sci 49(5)

      Pages: 2193-200

  • [Journal Article] 網膜電気刺激の臨床応用.2008

    • Author(s)
      篠田啓、角田和繁、尾関直毅、三宅養三、
    • Journal Title

      眼科 50(9)

      Pages: 1235-1249

  • [Presentation] ELECTROPHYSIOLOGICAL EVALUATION ON THE ELECTRICAL RETINAL STIMULATION FOR RETINAL DISEASE. ISCEV SYMPOSIUM : VISUAL ELECTROPHYSIOLOGY FOR RETINAL DISEASES.2011

    • Author(s)
      篠田啓
    • Organizer
      ASIA PASIFIC ACADEMY OF OPHTHALMOLOGY CONGRESS (APAO)
    • Place of Presentation
      AUSTRALIA
    • Year and Date
      20110320-20110324
  • [Presentation] CLINICAL APPLICATION OF THE ELECTRICAL RETINAL STIMULATION2010

    • Author(s)
      SHINODA K, OHDE H, TSUNODA K, HANAZONO G, INOMATA K, MATSUMOTO CS, MIZOTA A, OZEKI N, KIMURA I, MIYAKE Y
    • Organizer
      INTERNATIONAL SOCIETY FOR CLINICALELECTROPHYSIOLOGY OF VISION (48TH)
    • Place of Presentation
      PERTH, AUSTRALIA
    • Year and Date
      20101100
  • [Presentation] TRANSCORNEAL ELECTRICAL STIMULATION ON A PATIENT WITH BEST VITELLIFORM MACULAR DYSTROPHY.2010

    • Author(s)
      尾関直毅, 篠田啓, 角田和繁
    • Organizer
      INTERNATIONAL SOCIETY FOR CLINICAL ELECTROPHYSIOLOGY OF VISION (48TH)
    • Place of Presentation
      PERTH, AUSTRALIA
    • Year and Date
      20101100
  • [Presentation] 連続ウェーブレット関数を用いたERG の波形成分の抽出と分析2010

    • Author(s)
      松本惣一セルソ、篠田啓
    • Organizer
      第58回日本臨床視覚電気生理学会.
    • Place of Presentation
      岩手
    • Year and Date
      20101000
  • [Presentation] 液晶ディスプレイを用いたパターンVEP記録.2010

    • Author(s)
      篠田啓、松本惣一セルソ
    • Organizer
      第58回日本臨床視覚電気生理学会.
    • Place of Presentation
      岩手
    • Year and Date
      20101000
  • [Presentation] 網膜色素変性症に酷似した小口病の1例.2010

    • Author(s)
      園山裕子、三宅養三、篠田啓
    • Organizer
      第58回日本臨床視覚電気生理学会.
    • Place of Presentation
      岩手
    • Year and Date
      20101000
  • [Presentation] HOW IS THE OBJECT IN THE VITREOUS CAVITY PERCEIVED?2010

    • Author(s)
      Shinoda K, Matsumoto CS, Miyake Y
    • Organizer
      International Symposium in honour of Prof.
    • Place of Presentation
      G.B. Arden's 80th birthday
    • Year and Date
      20100609-20100611
  • [Presentation] Clinical Features of Occult Macular Dystrophy in a Large Japanese Family.2010

    • Author(s)
      Tsunoda K, Shinoda K, Miyake Y
    • Organizer
      The Association for Research in Vision and Ophthalmology (43rd).
    • Place of Presentation
      Fort Lauderdale, Florida
    • Year and Date
      20100502-20100506
  • [Presentation] Analysis of Oscillation Potentials in a Photopic Electroretinogram Using Continuous Wavelet Transform.2010

    • Author(s)
      松本惣一セルソ, 篠田啓
    • Organizer
      The Association for Research in Vision and Ophthalmology (43rd).
    • Place of Presentation
      Fort Lauderdale, Florida
    • Year and Date
      20100502-20100506
  • [Presentation] Good Correlation of Scotopic and Photopic ERG Components With Severity of Ocular Circulation Disturbances Following Central Retinal Artery Occlusion.2010

    • Author(s)
      篠田啓, 松本惣一セルソ
    • Organizer
      The Association for Research in Vision and Ophthalmology (43rd).
    • Place of Presentation
      Fort Lauderdale, Florida
    • Year and Date
      20100502-20100506
  • [Presentation] 視覚生理の臨床.特別講演.2010

    • Author(s)
      篠田啓
    • Organizer
      第32回城北地区学術講演会.
    • Place of Presentation
      東京
    • Year and Date
      2010-11-20
  • [Presentation] 視覚生理の臨床.2010

    • Author(s)
      篠田啓
    • Organizer
      第10回北海道眼科ワークショップ.
    • Place of Presentation
      札幌
    • Year and Date
      2010-10-23
  • [Presentation] 臨床現場の視覚生理学.2010

    • Author(s)
      篠田啓
    • Organizer
      第38回青森県手術懇話会.
    • Place of Presentation
      青森
    • Year and Date
      2010-08-07
  • [Presentation] 網膜色素変性症人工網膜研究開発:ドイツの現状.2010

    • Author(s)
      篠田啓
    • Organizer
      第9回JRPS東京支部定期総会医療講演.
    • Place of Presentation
      東京
    • Year and Date
      2010-05-16
  • [Presentation] 網膜色素変性症に網膜電気刺激療法を行った1例.2010

    • Author(s)
      猪俣公一、篠田啓、湯澤美都子
    • Organizer
      第766回東京都眼科集談会.
    • Place of Presentation
      東京
    • Year and Date
      2010-05-13
  • [Presentation] プライマリ・ケア・シリーズ48(日常診療におけるERG 日常診療に役立つ電気生理)2010

    • Author(s)
      篠田啓
    • Organizer
      日本眼科学会専門医制度第52回講習会.
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-17
  • [Presentation] 僕の臨床視覚研究.2010

    • Author(s)
      篠田啓
    • Organizer
      第5回多摩眼科フォーラム.
    • Place of Presentation
      東京
    • Year and Date
      2010-03-20
  • [Presentation] 光干渉断層計による小口病の網膜外層評価.2009

    • Author(s)
      松本惣一セルソ、篠田啓
    • Organizer
      第57回日本臨床視覚電気生理学会.
    • Place of Presentation
      千葉
    • Year and Date
      20091000
  • [Presentation] 錐体ERGのPhotopic hillに関する一考察.2009

    • Author(s)
      三宅養三、花園元、角田和繁、藤波芳、篠田啓、松本惣一セルソ、船田英明
    • Organizer
      第57回日本臨床視覚電気生理学会.
    • Place of Presentation
      千葉
    • Year and Date
      20091000
  • [Presentation] 網膜剥離眼の循環評価.2009

    • Author(s)
      篠田啓
    • Organizer
      第3回硝子体手術フォーラム.
    • Place of Presentation
      ルスツ
    • Year and Date
      20090204-20090205
  • [Presentation] 'Clinical features of occult macular dystrophy in a large family in Japan' International Society for Clinical Electrophysiology of Vision (ISCEV).2009

    • Author(s)
      Tsunoda K, Shinoda K, Miyake Y
    • Organizer
      47th Symposium.
    • Place of Presentation
      Padova, Italy
    • Year and Date
      2009-07-09
  • [Presentation] 'What we learn from unilateral retinal dystrophy?' International Society for Clinical Electrophysiology of Vision (ISCEV).2009

    • Author(s)
      Miyake Y, Hanazono G, Tsunoda K, Shinoda K, Fujinami K, Kondo M
    • Organizer
      47th Symposium.
    • Place of Presentation
      Padova, Italy
    • Year and Date
      2009-07-09
  • [Presentation] 感覚代行.(特別講演)2008

    • Author(s)
      篠田啓
    • Organizer
      第152回大分眼科集談会.
    • Place of Presentation
      大分
    • Year and Date
      20081200
  • [Presentation] 視覚代行.2008

    • Author(s)
      篠田啓
    • Organizer
      第191回高知大学眼科研究会.
    • Place of Presentation
      高知
    • Year and Date
      20081080
  • [Presentation] 経角膜電気刺激にて視力改善を認めたBEST病の1症例.2008

    • Author(s)
      尾関直毅、篠田啓
    • Organizer
      第62回日本臨床眼科学会.
    • Place of Presentation
      東京
    • Year and Date
      20081000
  • [Presentation] スペクトログラム関数とウェーブレット関数を用いたERGの周波数解析.2008

    • Author(s)
      松本惣一セルソ、篠田啓
    • Organizer
      第56回日本臨床視覚電気生理学会.
    • Place of Presentation
      東京
    • Year and Date
      20080900
  • [Presentation] Changes in Retinal Thickness is Correlated with Alterations of Electroretinogram in Eyes with Central Retinal Artery Occlusion.2008

    • Author(s)
      篠田啓, 松本惣一セルソ
    • Organizer
      World Ophthalmology Congress.
    • Year and Date
      20080628-20080702
  • [Presentation] 経角膜電気治療.眼科における電気治療の可能性.2008

    • Author(s)
      篠田啓
    • Organizer
      抗加齢医学研究会講習会.
    • Place of Presentation
      東京
    • Year and Date
      2008-11-20
  • [Book] 人工網膜研究開発:ドイツの現状.SSKAあぁるぴぃ東京支部だより.2010

    • Author(s)
      篠田啓
    • Total Pages
      1-11
    • Publisher
      障害者団体定期刊行物協会
  • [Book] 黄斑低形成とはどのような病態なのか.眼のサイエンス視覚の不思議.2010

    • Author(s)
      篠田啓
    • Total Pages
      142-144
    • Publisher
      文光堂
  • [Book] 臨床ERG,運・鈍・根.2008

    • Author(s)
      三宅養三、大出尚郎、篠田啓、角田和繁、木村至
    • Total Pages
      1-204
    • Publisher
      銀海舎
  • [Book] 遺伝性黄斑疾患の眼底検査.樋田哲夫、江口秀一郎編集、眼科診療のコツと落とし穴3検査・診断.2008

    • Author(s)
      篠田啓
    • Total Pages
      134-135
    • Publisher
      中山書店

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Published: 2012-01-26   Modified: 2016-04-21  

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