2010 Fiscal Year Final Research Report
Clarification of the three-dimensional structure of vascular malformations by objective differentiation between blood vessels and lymphatic vessels, and its clinical application
| Project/Area Number |
20592098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
ICHINOSE Akihiro Kobe University, 医学部附属病院, 准教授 (90362780)
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| Co-Investigator(Kenkyū-buntansha) |
TAHARA Shinya 神戸大学, 医学部附属病院, 教授 (30276894)
ISHIKAWA Yukio 東邦大学, 医学部, 准教授 (30276894)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 脈管奇形 / 血管内皮細胞 / リンパ管内皮細胞 |
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| Research Abstract |
Immunohistochemical examinations were performed on the morbid vessels of vascular malformations using bountiful immunohistochemical markers of vascular endothelial cells including LYVE-1 antibodies, which we had recently developed. This study demonstrated that various patterns of immunohistochemical markers were expressed in vascular malformations which could be classified in the same category of vascular malformations such as either lymphatic vessel malformations or venous malformations. This suggests that they follow a different pathogenesis. In addition, the immunohistochemical method has made it easier to properly diagnosis the pathology of various microvessels. It has been demonstrated that this method is useful for accurate diagnosis of microinvasion into the small lymph vessels during the early stages of gastroenterological carcinoma and in determining the proper management of coronary disorders.
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