2010 Fiscal Year Final Research Report
The development of cartilage regeneration methods using the human auricular cartilage progenitor cells in craniofacial deformity.
| Project/Area Number |
20592101
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
KOBAYASHI Shinji Yokohama City University, 医学研究科, 客員研究員 (90464536)
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| Co-Investigator(Renkei-kenkyūsha) |
MAEGAWA Jirou 横浜市立大学, 附属病院, 准教授 (70244449)
TANIGUCHI Hideki 横浜市立大学, 医学研究科, 教授 (70292555)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 再生医学 |
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| Research Abstract |
Human cartilage progenitor cells(hCPCs), which were isolated from auricular perichondrium had not only high proliferative and multipotent capacity that human condrocytes(hCs) did not have, but had same cartilage extracellular matrix capacity as hCs. Furthermore, in vivo hCPCs formed the cartilage with perichondrium as normal auricular cartilage. The hCPCs with hydroxyapatite/chondroitin sulfate composite also formed larger cartilage in vivo.
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