2010 Fiscal Year Final Research Report
Therapeutic Angiogenesis with oxygen application new biomaterials for chronic wounds
| Project/Area Number |
20592105
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Plastic surgery
|
|---|
| Research Institution | Saitama Medical University |
|---|
Principal Investigator |
ICHIOKA Shigeru Saitama Medical University, 医学部, 教授 (60306272)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 創傷治癒 / 再生医学 |
|---|
| Research Abstract |
Optimal oxygen environment for wound healing is still unknown.
The study aims to experimentally evaluate the wound healing dynamics under different oxygen environment.
We applied an oxygen non-permeable membrane (Polyvinylidene chloride, oxygen permeability : 40-90ml/m2・24hr・1atm) and an oxygen permeable membrane (Polymethylpentene, oxygen permeability : 60000-65000ml/m2・24hr・1atm) to excisional skin defects in ddy mice
Our result suggested that sufficient oxygen allowed adequate epithelialization and granulation formation. Enhanced neovascularization in the non-permeable group likely implies compensation of hypoxic condition.
|
