2010 Fiscal Year Final Research Report
Roles of cytoskeletal proteins in organic fibrosis and their application of therapy in fibrotic diseases
| Project/Area Number |
20592111
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kinki University |
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Principal Investigator |
YOSHIDA Koji Kinki University, 医学部, 准教授 (60230736)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Akio 近畿大学, 医学部, 講師 (40153788)
HAGIHARA Satoru 近畿大学, 医学部, 講師 (40460852)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 線維化 / 線維芽細胞 / transgelin / integrin α11 / CIB1 |
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| Research Abstract |
Activation of myofibroblasts was inhibited when the expression of transgelin was knocked down. When human lung fibroblasts were stimulated by TGF-β, the integrin α11 (ITGA11) expression was markedly increased. Calcium and integrin binding protein 1 (CIB1) bound to the intracellular domain of ITGA11. The expression of CIB1 increased in human lung fibroblasts treated with TGF-β and in bleomycin-treated mice pulmonary tissues. These results suggest that CIB1 may be involved in the fibrosis.
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